Journal ArticleDOI
Artemisia iwayomogi inhibits immediate-type allergic reaction and inflammatory cytokine secretion.
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TLDR
Evidence is provided that AIAE may be beneficial in the treatment of allergic diseases as it dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.Abstract:
The immediate-type allergic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Artemisia iwayomogi (AIAE) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. AIAE inhibited compound 48/80-induced systemic reactions in mice. AIAE decreased the passive cutaneous anaphylaxis (PCA) reaction activated by antidinitrophenyl (anti-DNP) IgE antibody. AIAE dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. These results provide evidence that AIAE may be beneficial in the treatment of allergic diseases.read more
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Literature-related discovery (LRD): Potential treatments for Multiple Sclerosis
TL;DR: The discovery generation methodology has been developed to the point where ODS LRD problems can be solved with no results or knowledge of any prior work, and large amounts of potential discovery are generated.
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Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice.
Hyun-Soo Shin,Jong-Min Han,Hyeong-Geug Kim,Min-Kyung Choi,Chang-Gue Son,Ho-ryong Yoo,Hyunkyung Jo,In-chan Seol +7 more
TL;DR: The ACE treatment is beneficial for atherosclerosis in arterial area and hyperlipidemia induced hepatic tissue steatosis and significantly normalized those alterations.
Journal ArticleDOI
Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model
TL;DR: Artemisia capillaris exerts greater hepatoprotective and anti-fibrotic effects as compared with AC via enhancing antioxidant capacity and downregulating fibrogentic cytokines.
Journal ArticleDOI
Aqueous extract of Artemisia capillaris exerts hepatoprotective action in alcohol-pyrazole-fed rat model.
Min-Kyung Choi,Jong-Min Han,Hyeong-Geug Kim,Jin-Suk Lee,Jong Suk Lee,Jing-Hua Wang,Seung-Wan Son,Hye-Jung Park,Chang-Gue Son +8 more
TL;DR: The results support the relevance in clinical use of Artemisia capillaris for alcohol-associated hepatic disorders and the underlying mechanisms may involve both enhancement of antioxidant activities and modulation of proinflammatory cytokines.
Journal ArticleDOI
Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation.
Jong-Min Han,Hyeong-Geug Kim,Min-Kyung Choi,Jin-Suk Lee,Hye-Jung Park,Jing-Hua Wang,Jong Suk Lee,Seung-Wan Son,Seock-Yeon Hwang,Chang-Gue Son +9 more
TL;DR: The data suggest that WAI may have antifibrotic properties via both improvement of antioxidant activities and inhibition of ECM protein production in the rat model of BDL.
References
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Journal Article
A method for the fluorometric assay of histamine in tissues
TL;DR: Gross dissection of brain showed no marked localization of brain histamine and a sensitive and specific fluorometric method for the estimation of histamine in tissues was described.
Journal ArticleDOI
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.
Marshall Plaut,Jacalyn H. Pierce,Cynthia J. Watson,J. Hanley-Hyde,Richard P. Nordan,William E. Paul +5 more
TL;DR: It is shown that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells).
Journal ArticleDOI
Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1.
TL;DR: It is demonstrated that human dermal mast cells contain sizeable stores of immunoreactive and biologically active TNF-alpha within granules, which can be released rapidly into the extracellular space upon degranulation.
Journal ArticleDOI
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.
P R Burd,H. W. Rogers,John R. Gordon,C. A. Martin,Sundararajan Jayaraman,S D Wilson,Ann M. Dvorak,Stephen J. Galli,Martin E. Dorf +8 more
TL;DR: It is suggested that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors.
Journal Article
Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.
P. Bradding,I. Feather,Susan J. Wilson,P. G. Bardin,C H Heusser,Stephen T. Holgate,Peter H. Howarth +6 more
TL;DR: Findings indicate that the mast cell is an important source of preformed cytokines and as such may contribute to the chronicity of the mucosal inflammation that characterizes allergic rhinitis.