Association between Exposure of Young Children to Procedures Requiring General Anesthesia and Learning and Behavioral Outcomes in a Population-based Birth Cohort.
Danqing Hu,Randall P. Flick,Michael J. Zaccariello,Robert C. Colligan,Slavica K. Katusic,Darrell R. Schroeder,Andrew C. Hanson,Shonie L. Buenvenida,Stephen J. Gleich,Robert T. Wilder,Juraj Sprung,David O. Warner +11 more
TLDR
Findings in children anesthetized with modern techniques largely confirm those found in an older birth cohort and provide additional evidence that children with multiple exposures are more likely to develop adverse outcomes related to learning and attention.Abstract:
Background
Exposure of young animals to general anesthesia (GA) causes neurodegeneration and lasting behavioral abnormalities; whether these findings translate to children remains unclear. This study used a population-based birth cohort to test the hypothesis that multiple, but not single, exposures to procedures requiring GA prior to age 3 years are associated with adverse neurodevelopmental outcomes.read more
Citations
More filters
Journal ArticleDOI
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
Andrew Davidson,Nicola Disma,Jurgen C. de Graaff,Davinia E. Withington,Liam Dorris,Graham Bell,Robyn Stargatt,Robyn Stargatt,David C. Bellinger,David C. Bellinger,Tibor Schuster,Sarah J Arnup,Pollyanna Hardy,Rodney W. Hunt,Rodney W. Hunt,Michael Takagi,Gaia Giribaldi,Penelope L Hartmann,Ida Salvo,Neil S. Morton,Britta S von Ungern Sternberg,Britta S von Ungern Sternberg,Bruno Guido Locatelli,Niall C. T. Wilton,Anne M. Lynn,Joss J. Thomas,David M. Polaner,Oliver Bagshaw,Peter Szmuk,Anthony Absalom,Geoff Frawley,Charles B. Berde,Gillian D Ormond,Jacki Marmor,Mary Ellen McCann +34 more
TL;DR: This trial found no evidence that just under an hour of sevoflurane anaesthesia in infancy increases the risk of adverse neurodevelopmental outcome at two years of age compared to RA.
Journal ArticleDOI
Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia: The Mayo Anesthesia Safety in Kids (MASK) Study.
David O. Warner,Michael J. Zaccariello,Slavica K. Katusic,Darrell R. Schroeder,Andrew C. Hanson,Phillip J. Schulte,Shonie L. Buenvenida,Stephen J. Gleich,Robert T. Wilder,Juraj Sprung,Danqing Hu,Robert G. Voigt,Merle G. Paule,John J. Chelonis,Randall P. Flick +14 more
TL;DR: The hypothesis that exposure to multiple, but not single, procedures requiring anesthesia before age 3 yr is associated with adverse neurodevelopmental outcomes is suggested, and changes in specific neuropsychological domains that are associated with behavioral and learning difficulties are suggested.
Journal ArticleDOI
Directed acyclic graphs: a tool for causal studies in paediatrics.
Thomas C Williams,Cathrine Carlsen Bach,Niels Bjerregård Matthiesen,Tine Brink Henriksen,Luigi Gagliardi +4 more
TL;DR: DAGs are a graphical tool which provide a way to visually represent and better understand the key concepts of exposure, outcome, causation, confounding, and bias and it is shown how DAGs can be most useful in identifying confounding and sources of bias.
Journal ArticleDOI
Long-term Differences in Language and Cognitive Function after Childhood Exposure to Anesthesia
Journal ArticleDOI
Clinical Evidence for Any Effect of Anesthesia on the Developing Brain
Andrew Davidson,Lena S. Sun +1 more
TL;DR: Most, but not all, of the large population-based studies find evidence for associations between surgery in early childhood and slightly worse subsequent academic achievement or increased risk for later diagnosis of a behavioral disability.
References
More filters
Journal ArticleDOI
Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits
Vesna Jevtovic-Todorovic,Richard E. Hartman,Yukitoshi Izumi,N. Benshoff,Krikor Dikranian,Charles F. Zorumski,John W. Olney,David F. Wozniak +7 more
TL;DR: A combination of drugs commonly used in pediatric anesthesia in doses sufficient to maintain a surgical plane of anesthesia is administered to 7-d-old infant rats, and it is observed that this causes widespread apoptotic neurodegeneration in the developing brain, deficits in hippocampal synaptic function, and persistent memory/learning impairments.
Journal ArticleDOI
Early Exposure to Anesthesia and Learning Disabilities in a Population-Based Birth Cohort
Robert T. Wilder,Randall P. Flick,Juraj Sprung,Slavica K. Katusic,William J. Barbaresi,Christopher Mickelson,Stephen J. Gleich,Darrell R. Schroeder,Amy L. Weaver,David O. Warner +9 more
TL;DR: Exposure to anesthesia was a significant risk factor for the later development of LD in children receiving multiple, but not single anesthetics in this cohort, but these data cannot reveal whether anesthesia itself may contribute to LD or whether the need for anesthesia is a marker for other unidentified factors that contribute toLD.
Journal ArticleDOI
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
Andrew Davidson,Nicola Disma,Jurgen C. de Graaff,Davinia E. Withington,Liam Dorris,Graham Bell,Robyn Stargatt,Robyn Stargatt,David C. Bellinger,David C. Bellinger,Tibor Schuster,Sarah J Arnup,Pollyanna Hardy,Rodney W. Hunt,Rodney W. Hunt,Michael Takagi,Gaia Giribaldi,Penelope L Hartmann,Ida Salvo,Neil S. Morton,Britta S von Ungern Sternberg,Britta S von Ungern Sternberg,Bruno Guido Locatelli,Niall C. T. Wilton,Anne M. Lynn,Joss J. Thomas,David M. Polaner,Oliver Bagshaw,Peter Szmuk,Anthony Absalom,Geoff Frawley,Charles B. Berde,Gillian D Ormond,Jacki Marmor,Mary Ellen McCann +34 more
TL;DR: This trial found no evidence that just under an hour of sevoflurane anaesthesia in infancy increases the risk of adverse neurodevelopmental outcome at two years of age compared to RA.
Journal ArticleDOI
Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery
Randall P. Flick,Slavica K. Katusic,Robert C. Colligan,Robert T. Wilder,Robert G. Voigt,Michael D. Olson,Juraj Sprung,Amy L. Weaver,Darrell R. Schroeder,David O. Warner +9 more
TL;DR: Repeated exposure to anesthesia and surgery before the age of 2 was a significant independent risk factor for the later development of LDs but not the need for educational interventions related to emotion/behavior.
Journal ArticleDOI
Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood
Lena S. Sun,Guohua Li,Tonya L. K. Miller,Cynthia F. Salorio,Mary W. Byrne,David C. Bellinger,Caleb Ing,Raymond Park,Jerilynn Radcliffe,Stephen R. Hays,Charles DiMaggio,Timothy J. Cooper,Virginia Rauh,Lynne G. Maxwell,Ahrim Youn,Francis X. McGowan +15 more
TL;DR: Among healthy children with a single anesthesia exposure before age 36 months, compared with healthy siblings with no anesthesia exposure, there were no statistically significant differences in IQ scores in later childhood.
Related Papers (5)
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
Andrew Davidson,Nicola Disma,Jurgen C. de Graaff,Davinia E. Withington,Liam Dorris,Graham Bell,Robyn Stargatt,Robyn Stargatt,David C. Bellinger,David C. Bellinger,Tibor Schuster,Sarah J Arnup,Pollyanna Hardy,Rodney W. Hunt,Rodney W. Hunt,Michael Takagi,Gaia Giribaldi,Penelope L Hartmann,Ida Salvo,Neil S. Morton,Britta S von Ungern Sternberg,Britta S von Ungern Sternberg,Bruno Guido Locatelli,Niall C. T. Wilton,Anne M. Lynn,Joss J. Thomas,David M. Polaner,Oliver Bagshaw,Peter Szmuk,Anthony Absalom,Geoff Frawley,Charles B. Berde,Gillian D Ormond,Jacki Marmor,Mary Ellen McCann +34 more