Journal ArticleDOI
Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway.
Songyi Cheng,Xiaoxiao Zhang,Qian Feng,Jiandong Chen,Le Shen,Peng Yu,Li Yang,Daohai Chen,Haowen Zhang,Weixin Sun,Xiaohu Chen +10 more
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TLDR
The study indicated that AS-IV could promote angiogenesis and cardioprotection after myocardial infarction and the mechanisms involve activation of PTEN/PI3K/Akt signaling pathway.About:
This article is published in Life Sciences.The article was published on 2019-06-15. It has received 79 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & PTEN.read more
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Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials
TL;DR: This review discusses the MQC mechanisms and how they are linked to cardiac microvascular ischemia-reperfusion (I/R) injury, and presents potential therapeutic interventions for improving MqC in cardiacmicrovascular I/R injury.
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Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis.
TL;DR: This review summarizes the pro-angiogenic activity and the mechanism of TCM formulas, extracts, and compounds and delivers an in-depth understanding of the relationship between TCM and pro-ANGiogenesis and will provide new ideas for clinical practice.
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Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases.
TL;DR: The mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.
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Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats
TL;DR: Astragaloside IV (AS-IV) is a primary active ingredient of Chinese herb Radix Astragali, which protects against acute cerebral ischemic/reperfusion injury through its antioxidant, anti-inflammatory, and anti-apoptotic properties as mentioned in this paper.
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Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress.
TL;DR: Advances in the use of active CHM components that modulate oxidative stress are reviewed, suggesting potential drugs for the treatment of various CVDs.
References
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The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
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Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
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Fourth Universal Definition of Myocardial Infarction (2018).
Kristian Thygesen,Joseph S. Alpert,Allan S. Jaffe,Bernard R. Chaitman,Jeroen J. Bax,David A. Morrow,Harvey D. White +6 more
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
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Regulation of angiogenesis by hypoxia: role of the HIF system.
TL;DR: The role of HIF in developmental, adaptive and neoplastic angiogenesis, and the implications of oncogenic activation of extensive, physiologically interconnected hypoxia pathways for the tumor phenotype are discussed.
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The inflammatory response in myocardial infarction
TL;DR: This review summarizes the current understanding of the cellular and molecular mechanisms regulating the inflammatory response following myocardial ischemia and reperfusion and concludes that by promoting more effective tissue repair, it may be possible to reduce the deleterious remodeling.