Journal ArticleDOI
Asymmetric aminocatalysis--gold rush in organic chemistry.
TLDR
This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development.Abstract:
Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well-established and powerful synthetic tool for the chemo- and enantioselective functionalization of carbonyl compounds. In the last eight years alone, this field has grown at such an extraordinary pace that it is now recognized as an independent area of synthetic chemistry, where the goal is the preparation of any chiral molecule in an efficient, rapid, and stereoselective manner. This has been made possible by the impressive level of scientific competition and high quality research generated in this area. This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development. As in all areas of science, progress depends on human effort.read more
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Organocatalytic cascade reactions as a new tool in total synthesis
TL;DR: The first applications of asymmetric organocatalytic cascade reactions to the total synthesis of natural products are presented, paving the way for a new and powerful strategy that can help to address these issues.
Journal ArticleDOI
Organocatalysis--after the gold rush.
TL;DR: This tutorial review will firstly sketch the basic developments in organocatalysis, focussing especially on the use of secondary amines as catalysts for the functionalization of aldehydes and alpha,beta-unsaturated aldeHydes, with emphasis on the mechanisms of the transformations and outline recent trends within central areas of this research topic.
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Catalytic C-C bond-forming multi-component cascade or domino reactions: pushing the boundaries of complexity in asymmetric organocatalysis.
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Photoredox catalysis with visible light.
TL;DR: Despite the obvious, practical advantages of visible light as an “infinitely available” promoter for chemical synthesis, the simple inability of most organic molecules to absorb light in the visible range of the spectrum has greatly limited the potential applications of photochemical reactions.
Journal ArticleDOI
N-heterocyclic carbene catalyzed domino reactions.
André Grossmann,Dieter Enders +1 more
TL;DR: A critical consideration of domino, cascade, and tandem catalysis in the case of N-heterocyclic carbenes catalysts is presented and recent publications in this area are highlighted.
References
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Journal ArticleDOI
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
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Asymmetric enamine catalysis.
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Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
Journal ArticleDOI
In the Golden Age of Organocatalysis
Peter I. Dalko,Lionel Moisan +1 more
TL;DR: The diverse examples show that in recent years organocatalysis has developed within organic chemistry into its own subdiscipline, whose "Golden Age" has already dawned.
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Cascade reactions in total synthesis.
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.