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Asystole complicating physostigmine treatment of tricyclic antidepressant overdose

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TLDR
Two patients with TCA toxicity who developed asystole following the administration of physostigmine to treat seizures are described.
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This article is published in Annals of Emergency Medicine.The article was published on 1980-11-01. It has received 165 citations till now. The article focuses on the topics: Tricyclic antidepressant overdose & Asystole.

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Part 12: Cardiac Arrest in Special Situations 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

TL;DR: This section of the 2010 AHA Guidelines for CPR and ECC addresses cardiac arrest in situations that require special treatments or procedures beyond those provided during basic life support (BLS) and advanced cardiovascular life support(ACLS).
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Journal ArticleDOI

Poisoning due to organophosphate insecticides. acute and chronic manifestations

TL;DR: Two patients with Diazinon ® poisoning and the second with parathion poisoning illustrate the acute manifestations, the criteria for diagnosis, and treatment with pralidoxime and atropine in organophosphate poisoning.
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Cholinergic Innervation of the Canine and Human Ventricular Conducting System Anatomic and Electrophysiologic Correlations

TL;DR: It is concluded that the enhanced ventricular electrical stability produced by vagal stimulation in dogs is mediated by cholinergic nerve fibers which supply the ventricular conduction system, and this anatomic pathway is present in human hearts.
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Tricyclic Antidepressant Overdose: Incidence of Symptoms

TL;DR: Plasma TCA measurements more reliably define patients who are at risk for major medical complications following overdose than does the amount of drug ingested by history.
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Physostigmine: Its Use in Acute Anticholinergic Syndrome With Antidepressant and Antiparkinson Drugs

TL;DR: Physostigmine, uniquely among the available reversible anticholinesterase agents, can pass the blood-brain barrier to exert central as well as peripheral cholinomimetic actions to reverse this syndrome of agitation and toxic confusional psychosis.
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Tricyclic Antidepressant Poisoning: Reversal of Coma, Choreoathetosis, and Myoclonus by Physostigmine

TL;DR: Physostigmine salicylate appears to be the drug of choice in tricyclic antidepressant poisoning as well as in treating classical anticholinergic intoxication, and can be used as a diagnostic test for suspected poisoning from these agents.
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