Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats
Maria Inês da Cruz Campos,Wellington Dorigheto Andrade Vieira,Celso Neiva Campos,Fernando Monteiro Aarestrup,Beatriz Julião Vieira Aarestrup +4 more
TLDR
Among the drugs selected, atorvastatin exhibited the best preventive potential in regards to leukopenia secondary to experimental chemotherapy induced by 5-FU, in comparison to the group receiving saline solution, while PTX amplified such alterations in the leukograms of the animals in this trial.Abstract:
Malignant neoplasia represents the second cause of disease-related mortality and, among all patients diagnosed with cancer, 70% will receive chemotherapy during the course of treatment. As a consequence, an increasing number of researchers have focused their attention on the search for more specific anticancer therapies associated with fewer side effects. Leukopenia is an important adverse effect associated with chemotherapy. Secondary infection is very common among leukopenic patients, directly affecting the continuity of the chemotherapeutic treatment and leading to possible complications in tumor immune defense. Atorvastatin, a type of statin, is a known agent used to control hypercholesterolemia. Trans-caryophyllene, isolated from a resinous oil extracted from the copaiba tree, possesses anti-inflammatory and analgesic properties. The AIM of the present study was to evaluate, through a complete leukocyte count, the systemic immunomodulation potential of pentoxifylline (PTX), atorvastatin and trans-caryophyllene, as well as the possible prophylactic role of these drugs against secondary leukopenia, in an experimental chemotherapy model induced by 5-fluorouracil (5-FU) in wistar rats. A total of 32 male wistar rats were used, 24 of which were submitted to treatment with atorvastatin, PTX and trans-caryophyllene prior to the administration of chemotherapy. The Shapiro-Wilk test was used to verify normality and the Kruskal-Wallis test was used for negative data in the normality test. Among the drugs selected, atorvastatin exhibited the best preventive potential in regards to leukopenia secondary to experimental chemotherapy induced by 5-FU, in comparison to the group receiving saline solution, while PTX amplified such alterations in the leukograms of the animals in this trial.read more
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β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
TL;DR: The selective activation of CB2 may be considered a novel strategy in pain treatment, devoid of psychoactive side effects associated with CB1 stimulation, and BCP as selective CB2 activator may be taken into account as potential natural analgesic drug.
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Polypharmacological Properties and Therapeutic Potential of β-Caryophyllene: A Dietary Phytocannabinoid of Pharmaceutical Promise.
Charu Sharma,Juma Al Kaabi,Syed M. Nurulain,Sameer N. Goyal,Mohammad Amjad Kamal,Shreesh Ojha +5 more
TL;DR: A comprehensive insight is provided of pharmacological and therapeutic potential of BCP, its molecular mechanism and signaling pathways in different pathological conditions and the possibility of its further development as a novel candidate for various pathologies considering the polypharmacological and multifaceted therapeutic properties potential.
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Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence.
Antonella Di Sotto,Romina Mancinelli,Marco Gullì,Margherita Eufemi,Caterina Loredana Mammola,Gabriela Mazzanti,Silvia Di Giacomo +6 more
TL;DR: Emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpenes characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests a possible usefulness of these natural substances in cancer chemoprevention for both preventive and adjuvant purposes.
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Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications.
Hebaallah Mamdouh Hashiesh,M.F. Nagoor Meeran,Charu Sharma,Bassem Sadek,Juma Al Kaabi,Shreesh Ojha +5 more
TL;DR: Given the safe status, abundant natural occurrence, oral bioavailability, dietary use and pleiotropic properties modulating receptors and enzymes, BCP appears as a promising molecule for diabetes and its complications.
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Inhibitory effect of trans-caryophyllene (TC) on leukocyte-endothelial attachment.
TL;DR: TC treatment in HUVECs prevented attachment of monocytic leukemia cell line THP‐1 cells to endothelial cells and in vivo results indicate that TC inhibited macrophage infiltration to the aortic surface and reduced total serum levels of cholesterol and triglycerides.
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