Journal ArticleDOI
ATP dependent conformational change in “spin labelled” sarcoplasmic reticulum
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TLDR
The effect of ATP suggests a conformational change due to simple binding of ATP to the membrane, similar to that of ATP, which was obtained with ADP, ITP and by increasing the pH of the membrane suspension above 9.1.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1969-01-01. It has received 69 citations till now. The article focuses on the topics: Conformational change & Denaturation (biochemistry).read more
Citations
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Rate of Calcium Binding and Uptake in Normal Animal and Failing Human Cardiac Muscle
Shoichi Harigaya,Arnold Schwartz +1 more
TL;DR: ATP was the most effective of four nucleoside triphosphates in supporting calcium binding and uptake and mitochondria accumulated calcium at a rate faster than CRS.
Journal ArticleDOI
Rate of Calcium Binding and Uptake in Normal Animal and Failing Human Cardiac Muscle: MEMBRANE VESICLES (RELAXING SYSTEM) AND MITOCHONDRIA
Shoichi Harigaya,Arnold Schwartz +1 more
TL;DR: In this paper, a modified rapid procedure was used to isolate the cardiac relaxing system (CRS) and mitochondria from human, rabbit, and dog, and the estimated initial binding rates (nmoles calcium/mg protein/minute) were 256, 1440 and 182, respectively.
Journal ArticleDOI
Cooperative calcium binding and ATPase activation in sarcoplasmic reticulum vesicles.
TL;DR: Equilib~um and kinetic analysis indicate the following mechanism for high affinity calcium binding and ATPase activation: E + Caa+ .+ E.Ca + E’oCa + Ca” -+ E”-Ca2.
Journal ArticleDOI
Kinetic analysis of ATPase mechanisms.
TL;DR: Since ATPases and ATP synthases are almost universally involved in some form of energy transduction there is a particular need in an ATPase or ATP synthase reaction to evaluate the equilibrium constants of the steps in the mechanism and to investigate the possibility of alternate reaction pathways.
Journal ArticleDOI
Current models for the structure of biological membranes
TL;DR: This paper presents a general evaluation of the Danielli model, which is based on the observation that a thin membrane which controls evidence had been so compelling that the conclusion that there exists on the and its environment was led to.
References
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Journal ArticleDOI
Adenosine triphosphate-linked concentration of calcium ions in a particulate fraction of rabbit muscle
Setsuro Ebashi,Fritz Lipmann +1 more
TL;DR: ATPase and ATP-dependent calcium ion concentration was studied with a membrane fraction isolated from homogenized rabbit skeletal muscle by differential centrifugation, indicating that it consists mainly of resealed tubules and vesicles of the endoplasmic reticulum.
Journal ArticleDOI
Reaction Mechanism of the Ca++-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle I. Kinetic Studies
Taibi Yamamoto,Yuji Tonomura +1 more
Journal ArticleDOI
On the Mechanism of the Relaxing Effect of Fragmented Sarcoplasmic Reticulum
TL;DR: Experiments suggest that the factor competes successfully with actomyosin for the available Ca through its mechanism of Ca accumulation, and that it has no other direct influence on the biological activity of actomyOSin.
Journal ArticleDOI
Effect of Diethyl Ether on the Adenosine Triphosphatase Activity and the Calcium Uptake of Fragmented Sarcoplasmic Reticulum of Rabbit Skeletal Muscle
TL;DR: Treatment of fragmented preparations of sarcoplasmic reticulum with diethyl ether decreases the calcium uptake capacity ofreticulum, while the ATP-binding capacity as well as the ATP/ATP-splitting activity of Reticulum were increased, while overoptimal concentrations of calcium exerted a competitive inhibition.
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Reaction Mechanism of the Ca++-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle I. Kinetic Studies
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