Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.
Brett Burstein,Stanley Nattel +1 more
TLDR
The current understanding of how atrial fibrosis creates a substrate for AF is reviewed, what is known about the mechanisms underlying fibrosis and its progression is summarized, and emerging therapeutic approaches aimed at attenuating structural remodeling to prevent AF are highlighted.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2008-02-26 and is currently open access. It has received 1067 citations till now. The article focuses on the topics: Angiotensin II & Fibrosis.read more
Citations
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2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: This document summarizes current research, plans, and recommendations for future research, as well as providing a history of the field and some of the techniques used, currently in use, at the National Institutes of Health.
Journal ArticleDOI
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease.
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Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal
TL;DR: A translational overview on the biological basis of atrial remodeling and the proarrhythmic mechanisms involved in the fibrillation process is given.
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Atrial remodeling and atrial fibrillation: mechanisms and implications.
TL;DR: The types of atrial remodeling, their underlying pathophysiology, the molecular basis of their occurrence, and finally, their potential therapeutic significance are reviewed.
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The Clinical Profile and Pathophysiology of Atrial Fibrillation Relationships Among Clinical Features, Epidemiology, and Mechanisms
TL;DR: Better recognition of the clinical epidemiology of AF, as well as an improved appreciation of the underlying mechanisms, is needed to develop improved methods for AF prevention and management.
References
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Atrial Fibrillation Begets Atrial Fibrillation A Study in Awake Chronically Instrumented Goats
TL;DR: Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF.
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Molecular Mechanisms of Myocardial Remodeling
TL;DR: This review focuses only on permanent modifications in relation to clinical dysfunction in cardiac remodeling secondary to myocardial infarction and/or arterial hypertension and includes a special section on the senescent heart, since CR is mainly a disease of the elderly.
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Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Andrea Frustaci,Cristina Chimenti,Fulvio Bellocci,Emanuela Morgante,Matteo A. Russo,Attilio Maseri +5 more
TL;DR: Abnormal atrial histology was uniformly found in multiple biopsy specimens in all patients with LAF and was compatible with a diagnosis of myocarditis in 66% of patients and of noninflammatory localized cardiomyopathy in 17% and was represented by patchy fibrosis in 17%.
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Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
Paul Milliez,Xavier Girerd,Pierre-François Plouin,Jacques Blacher,Michel E. Safar,Jean-Jacques Mourad +5 more
TL;DR: Patients presenting with PA experienced more cardiovascular events than did EHT patients independent of blood pressure, and the presence of PA should be detected, not only to determine the cause of HTN, but also to prevent such complications.
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Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort.
TL;DR: Experimental CHF strongly promotes the induction of sustained AF by causing interstitial fibrosis that interferes with local conduction, with important potential implications for understanding, treating, and preventing AF related to CHF.