Autoimmune Thyroid Diseases and Thyroid Cancer in Pemphigus: A Big Data Analysis.
TLDR
Hashimoto's thyroiditis was found to be associated with pemphigus only among male patients, but not among all patients, and this study does not provide a clue for an association of pemPHigus with Grave’s disease or thyroid cancer.Abstract:
There is a little consensus regarding the association of pemphigus with autoimmune thyroid diseases. While this association had been confirmed by some observational studies, others had refuted it. We aimed to study the association between pemphigus and Hashimoto's thyroiditis, Grave's disease, and thyroid cancer using a large-scale real-life computerized database. A cross-sectional study was performed to compare pemphigus patients with age-, sex-, and ethnicity-matched control subjects regarding the prevalence of overt thyroid diseases. Chi-square and t-tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed using the computerized database of Clalit Healthcare Services ensuring 4.5 million individuals. A total of 1,985 pemphigus patients and 9,874 controls were included in the study. The prevalence of Hashimoto's thyroiditis (12.9 vs. 11.9%; P = 0.228), Graves's disease (0.7 vs. 0.7%; P = 0.986), and thyroid cancer (0.7 vs. 0.5%; P = 0.305) were comparable among patients with pemphigus and control subjects. In sex-stratified analysis, pemphigus associated significantly with Hashimoto's thyroiditis among male patients (OR, 1.36; 95% CI, 1.04-1.79). In multivariate analysis adjusting for potential confounding factors, no independent associations between the conditions were revealed. Study findings were robust to sensitivity analysis that included only patients under pemphigus-specific treatments. In conclusion, Hashimoto's thyroiditis was found to be associated with pemphigus only among male patients, but not among all patients. Physicians treating patients with pemphigus might be aware of this possible association. This study does not provide a clue for an association of pemphigus with Grave's disease or thyroid cancer.read more
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Thyroid autoimmune disorders and cancer
Silvia Martina Ferrari,Poupak Fallahi,Giusy Elia,Francesca Ragusa,Ilaria Ruffilli,Sabrina Rosaria Paparo,Alessandro Antonelli +6 more
TL;DR: Future studies will be necessary to understand the connections between thyroid autoimmunity and cancer, also in order to design a tailored therapy for TC patients with AITD.
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Oral lichen planus and thyroid gland diseases: possible associations
TL;DR: It is found that there are no significant associations between the co-existence of OLP and TGD or related-medications, in agreement with some of the previously published similar studies but in controversy with others.
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Patients with pemphigus are at an increased risk of developing rheumatoid arthritis: a large-scale cohort study
Khalaf Kridin,Virginia A. Jones,Payal M. Patel,Shira Zelber-Sagi,Christoph M. Hammers,Giovanni Damiani,Kyle T. Amber,Arnon D. Cohen +7 more
TL;DR: It is concluded that pemphigus is associated with an increased risk of rheumatoid arthritis and Physicians treating patients with pemPHigus should be aware of this possible association.
Journal ArticleDOI
Hidradenitis suppurativa and pemphigus: a cross-sectional study.
Khalaf Kridin,Virginia A. Jones,Payal M. Patel,Frederick T Gibson,Kyle T. Amber,Arnon D. Cohen +5 more
TL;DR: The study detected a significant association between HS and pemphigus in an Israeli population and future prospective studies are needed to establish a temporal order of appearance and the mechanistic relationship between these entities.
Journal ArticleDOI
Serum Detection of Anti-thyroid Peroxidase and Anti-thyroglobulin Antibodies in Chinese Patients With Pemphigus Vulgaris and Pemphigus Foliaceus and Literature Review.
He-Xiao Wang,Yang Yang,Jing-Yuan Hu,Liming Zhang,Yun-Fei Cai,Hao Guo,Ting Xiao,Hong-Duo Chen,Xing-Hua Gao,Shuai Qiao +9 more
TL;DR: Wang et al. as mentioned in this paper investigated the levels and antibody positivity of anti-TPO and anti-Tg antibodies in pemphigus patients and found a significant correlation between increased presence of positive anti-, anti-, peroxidase (TPO) and anti-, antithyroglobulin (anti-) antibodies and pemophigus vulgaris (PV).
References
More filters
Journal ArticleDOI
Systematic Review: Process of Forming Academic Service Partnerships to Reform Clinical Education
TL;DR: This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education.
Journal ArticleDOI
A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation☆
TL;DR: The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
Development and Validation of A
TL;DR: The results suggest that the LJQ is a reliable and valid instrument for evaluating LJ.
BookDOI
The Autoimmune Diseases
Noel R. Rose,Ian R. Mackay +1 more
TL;DR: The biological basis of disease at genetic, molecular, cellular, and epidemiologic levels is discussed and tissue-specific interventions to arrest or cure autoimmune disease are discussed.
Journal ArticleDOI
Suppression situations in psychological research : definitions, implications, and applications
Joseph Tzelgov,Avishai Henik +1 more
TL;DR: A general approach to the analysis of suppression situations is presented in this paper, which is based on coupling three variate suppression situations with the applications of the concept of suppressor to the general linear model.