Ayurgenomics and Modern Medicine.
TLDR
The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health.Abstract:
Within the disciplines of modern medicine, P4 medicine is emerging as a new field which focuses on the whole patient. The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health. One of the most difficult challenges today is understanding the ancient concepts of Ayurveda in terms of modern science. To date, a number of researchers have attempted this task, of which one of the most successful outcomes is the creation of the new field of Ayurgenomics. Ayurgenomics integrates concepts in Ayurveda, such as Prakriti, with modern genetics research. It correlates the combination of three doshas, Vata, Pitta and Kapha, with the expression of specific genes and physiological characteristics. It also helps to interpret Ayurveda as an ancient science of epigenetics which assesses the current state of the doshas, and uses specific personalized diet and lifestyle recommendations to improve a patient's health. This review provides a current update of this emerging field.read more
Citations
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The Future of Medicine: Frontiers in Integrative Health and Medicine
TL;DR: Despite advances in modern medicine, contemporary society has experienced a series of epidemics and pandemics of noncommunicable, chronic diseases and communicable, infectious diseases as discussed by the authors, which has been referred to as pandemic epidemics.
Journal ArticleDOI
An Ayurgenomics Approach: Prakriti-Based Drug Discovery and Development for Personalized Care
Zoufang Huang,Vivek P. Chavda,Rajashri Bezbaruah,Vladimir N. Uversky,S. P.,Aayushi Patel,Zhenhua Chen +6 more
TL;DR: This work tries to understand prakriti’s use in personalized medicine, and how to integrate it with programs for drug development and discovery.
Journal ArticleDOI
Ayurnutrigenomics – a step towards personalized nutrition
TL;DR: The novel concept of Ayurnutrigenomics is an innovative perception of nutrigenomic research for developing personalized functional foods and nutraceuticals suitable for one's genetic makeup with the help of Ayurveda.
Journal ArticleDOI
Integrating ayurvedic medicine into cancer research programs part 1: Ayurveda background and applications
TL;DR: Ayurveda has an abundant resource of botanical products containing diverse pharmaco-active ingredients and millennia of experience of clinical applications for health benefits, but there is a lack of evidence-based research to demonstrate its efficacy and potential as discussed by the authors .
Journal ArticleDOI
Neuroadaptability and Habit: Modern Medicine and Ayurveda.
Robert Keith Wallace,Ted Wallace +1 more
TL;DR: In this paper, the authors examine neuroadaptability and how it affects health from the perspective of modern medicine and Ayurveda and examine the effect of these threats/challenges on individuals' health.
References
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Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda
Bhavana Prasher,Sapna Negi,Shilpi Aggarwal,A. Mandal,Tav P Sethi,S.R. Deshmukh,Sudha G Purohit,Shantanu Sengupta,Sangeeta Khanna,Farhan Mohammad,Gaurav Garg,Samir K. Brahmachari,Mitali Mukerji +12 more
TL;DR: This study makes a first attempt towards unraveling the clinical phenotyping principle of a traditional system of medicine in terms of modern biology using Ayurveda based method of phenotypic classification of extreme constitutional types.
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EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda
Shilpi Aggarwal,Sapna Negi,Pankaj Jha,Prashant Singh,Tsering Stobdan,M. A. Qadar Pasha,Saurabh Ghosh,Anurag Agrawal,Bhavana Prasher,Mitali Mukerji +9 more
TL;DR: A link between high-altitude adaptation and common variations rs479200 (C/T) and rs480902 (T/C) in the EGLN1 gene is reported, and a genotype rare in highlanders but overrepresented in a subgroup of normal lowlanders discernable by Ayurveda may confer increased risk for high-ALTitude pulmonary edema.
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Ayurvedic genomics: establishing a genetic basis for mind-body typologies.
TL;DR: The findings of a Genetic basis for both Ayurvedic and TCM classifications indicate a commonality between Asia's great medical traditions in their diagnostic typologies and a genetic basis for Asian traditional medicine's theory of discrete and discernable groupings of psycho-physiologic differences.
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Traditional Medicine to Modern Pharmacogenomics: Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability
TL;DR: Interesting correlations between CYP2C19 genotypes and Prakriti with fast and slow metabolism being one of the major distinguishing and differentiating characteristics are observed.
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Genome-wide analysis correlates Ayurveda Prakriti
Periyasamy Govindaraj,Sheikh Nizamuddin,Anugula Sharath,Vuskamalla Jyothi,Harish Rotti,Ritu Raval,Jayakrishna Nayak,Balakrishna K Bhat,B V Prasanna,Pooja Shintre,Mayura Sule,Kalpana Joshi,Amrish P. Dedge,Ramachandra Bharadwaj,G G Gangadharan,Sreekumaran Nair,P. M. Gopinath,Bhushan Patwardhan,Paturu Kondaiah,Kapaettu Satyamoorthy,M. S. Valiathan,Kumarasamy Thangaraj +21 more
TL;DR: It is found that PGM1 correlates with phenotype of Pitta as described in the ancient text of Caraka Samhita, suggesting that the phenotypic classification of India’s traditional medicine has a genetic basis.