Journal ArticleDOI
Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: A study just before mass hepatitis B vaccination program in Taiwan
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In this article, radioimmunoassays in serum samples of 1,200 (647 male, 553 female) apparently healthy children under 15 years of age in Taipei between June and October 1984.Abstract:
Hepatitis B virus (HBV) markers were studied by radioimmunoassays in serum samples of 1,200 (647 male, 553 female) apparently healthy children under 15 years of age in Taipei between June and October 1984. The prevalence rate of hepatitis B surface antigen (HBsAg) was 5.1% in infancy, increased to 10.7% between 1 and 2 years of age, and then remained constant at about 10% thereafter. The prevalence rate of surface antibody (anti-HBs), core antibody (anti-HBc), and seropositivity (at least one marker of hepatitis B detectable) were 39.0, 30.5, and 52.5%, respectively, in infancy, then decreased to 10.7, 14.3, and 17.9%, respectively, between 1 and 2 years of age. Thereafter, the antibody prevalence increased in parallel with age. By the age of 13–14 years, nearly half of the children were infected by HBV. The results suggested that in our children, most HBsAg carriers resulted from infections before 3 years of age, and HBV infections after 3 years of age infrequently resulted in a carrier state. One hundred (83.3%) of the 120 HBsAg-positive children had hepatitis B e antigen (HBeAg), indicating high prevalence in young asymptomatic HBsAg carriers. The prevalence rate of HBeAg tended to decrease with age and a reversed trend was observed with anti-HBe. Our study, just before our government extends mass hepatitis B vaccination program from newborns to children, provides background seroepidemiologic data of HBV infections in the healthy children in Taiwan.read more
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Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Shiv Kumar Sarin,Manoj Kumar,George K. K. Lau,Zaigham Abbas,Henry Lik-Yuen Chan,Chien-Jen Chen,Ding-Shinn Chen,Huey-Ling Chen,Pei-Jer Chen,Rong-Nan Chien,Abdul Kadir Dokmeci,Edward Gane,J L Hou,Wasim Jafri,Jidong Jia,J. H. Kim,Ching-Lung Lai,Hon Cheung Lee,Seng Gee Lim,Chun-Jen Liu,Stephen Locarnini,M. Al Mahtab,Rosmawati Mohamed,Masao Omata,Jun Yong Park,Teerha Piratvisuth,Barjesh Chander Sharma,Jose D. Sollano,Fu-Sheng Wang,Lai Wei,Man-Fung Yuen,Shusen Zheng,Jia-Horng Kao +32 more
TL;DR: The final clinical practice guidelines and recommendations for the optimal management of chronic HBV infection are presented here, along with the relevant background information.
Journal ArticleDOI
Hepatitis B virus infection
TL;DR: Developing new therapies that can improve HBsAg clearance and virological cure is warranted because long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma.
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Seroepidemiology of hepatitis B virus infection in children : Ten Years of mass vaccination in Taiwan
Huey-Ling Chen,Mei-Hwei Chang,Yen-Hsuen Ni,Hong-Yuan Hsu,Ping-lng Lee,Chin-Yun Lee,Ding-Shinn Chen +6 more
TL;DR: The Taiwanese mass vaccination program has protected most children younger than 10 years from becoming carriers, reducing both perinatal and horizontal HBV transmission and has proved to be a successful method to control HBV infection in this hyperendemic area.
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Hepatitis B Virus Infection in Children and Adolescents in a Hyperendemic Area: 15 Years after Mass Hepatitis B Vaccination
Yen-Hsuan Ni,Mei-Hwei Chang,Li-Min Huang,Huey-Ling Chen,Hong-Yuan Hsu,Tai-Yuan Chiu,Keh-Sung Tsai,Ding-Shinn Chen +7 more
TL;DR: The vaccination coverage rate was defined as the percentage of children receiving at least three doses of HBV vaccine, and the vaccination histories of the studied population were assessed by examining their vaccination cards and by taking a history from their parents.
References
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Vertical transmission of hepatitis B antigen in Taiwan.
TL;DR: It is indicated that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.
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Prevention of perinatally transmitted hepatitis b virus infections with hepatitis b immune globulin and hepatitis b vaccine
R. Palmer Beasley,R. Palmer Beasley,George Chin-Yun Lee,George Chin-Yun Lee,Cheng Hsiung Roan,Cheng Hsiung Roan,Lu-Yu Hwang,Lu-Yu Hwang,Chung Chi Lan,Chung Chi Lan,Fu Yuan Huang,Fu Yuan Huang,Chiung Lin Chen,Chiung Lin Chen +13 more
TL;DR: With HBIG coverage from birth, the timing of the start of vaccination does not seem to be of importance within the first month of life, but to maximise compliance and minimise costs hepatitis B vaccination should be initiated during the confinement.
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E Antigen and Anti-E in the Serum of Asymptomatic Carrier Mothers as Indicators of Positive and Negative Transmission of Hepatitis B Virus to Their Infants
TL;DR: E antigen may be used as an indicator of transmission, and antibody to e as that of absence of transmission of hepatitis B virus from carrier mothers to children, according to results of testing of serum samples of 23 pregnant women.
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THE e ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS B SURFACE ANTIGEN
TL;DR: Maternal e antigenemia correlated with a high HBsAg titer, and both parameters were equally good predictors of vertical transmission.