Journal ArticleDOI
Vertical transmission of hepatitis B antigen in Taiwan.
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TLDR
It is indicated that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.Abstract:
To determine the frequency of vertical transmission of hepatitis B antigen (HB5 Ag) from asymptomatic carrier mothers in Taiwan to their offspring, HB5 Ag was sought by radioimmunoassay and complement fixation. Of 158 babies born to carrier mothers, antigenemia developed in 63; 51 of these antigenemic babies had become antigen positive within the six months of life. Three inter-related factors were found to increase the risk that antigenemia would develop in the infant: a high maternal complement-fixation titer for HB5 Ag: presence of HB5 Ag in the baby's umbilical-cord blood: and antigenemia in siblings. In contrast to previous studies, these findings indicate that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.read more
Citations
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Hepatitis B Virus Infection — Natural History and Clinical Consequences
Don Ganem,Alfred M. Prince +1 more
TL;DR: The structure and replication cycle of hepatitis B virus is examined and the natural history of primary infection, the mechanisms of clearance of the virus, and reasons for persistent infection are discussed.
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Mei-Hwei Chang,Chien-Jen Chen,Mei-Shu Lai,Hsu-Mei Hsu,Tzee-Chung Wu,Man-Shan Kong,Der-Cherng Liang,Wen-Yi Shau,Ding-Shinn Chen +8 more
TL;DR: The incidence of hepatocellular carcinoma in children in Taiwan from 1981 to 1994 has declined since the institution of Taiwan's program of universal hepatitis B vaccination, and the corresponding rates of mortality have decreased.
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Hepatitis B Virus Biology
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European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease.
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TL;DR: The treatment of inflammatory bowel disease has been revolutionised over the past decade by the increasing use of immunomodulators, mainly azathioprine/6-mercaptopurine and methotrexate, together with the advent of biological therapy.
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Hepatitis B virus infection
TL;DR: Developing new therapies that can improve HBsAg clearance and virological cure is warranted because long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma.
References
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Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis
Girish N. Vyas,N. R. Shulman +1 more
TL;DR: The hemagglutination test has the sensitivity and rapidity of the best tests available, is simpler to perform, and lends itself to large-scale screening of blood donors.
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TL;DR: The relationship of these Australia (Au) particles to the infective agent itself is still unresolved, but present evidence suggests that they are fragments of viral lipoprotein envelope.
Journal Article
Detection of Additional Antigenic Determinants of Hepatitis B Antigen
TL;DR: Preliminary data suggest w is more common that r on HB Ag in the United States, but r is most common in Thailand, and further study after absorbing the antisersa with heterologous antigens indicated that the reference antisera were distinguishing two additional antigenic determinants, designated w and r.
Journal ArticleDOI
Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation.
TL;DR: Complement fixation techniques are described for measuring a virus-like antigen associated with viral hepatitis, which was found in the blood of 98 percent of 130 patients, with the serum form of hepatitis, from whom multiple samples were obtained.
Journal ArticleDOI
Hepatitis-associated antigen and hepatocellular carcinoma in Taiwan.
Myron J. Tong,Shih-Chien Sun,Berton T. Schaeffer,Nai-Kwei Chang,Kwang-Juei Lo,Robert L. Peters +5 more
TL;DR: Serums from 55 patients with primary hepatocellular carcinoma were examined for the presence of hepatitis-associated antigen (HAA), and forty-four had the antigen in their serums.