Open Access
Beneficial health effects of modest weight loss.
TLDR
In conclusion, a large proportion of obese individuals with NIDDM, hypertension, and hyperlipidemia experienced positive health benefits with modest weight loss, and even a small amount of weight loss appears to benefit a substantial subset of obese patients.Abstract:
The medical effects of modest weight reduction (approximately 10% or less) in patients with obesity-associated medical complications were reviewed. The National Library of Medicine MEDLINE database and the Derwent RINGDOC database were searched to identify English language studies that examined the effects of weight loss in obese patients with serious medical complications commonly associated with obesity (non-insulin dependent diabetes mellitus (NIDDM or type II), hypertension, hyperlipidemia, hypercholesterolemia, and cardiovascular disease). Studies in which patients experienced approximately 10% or less weight reduction were selected for review. Studies indicated that, for obese patients with NIDDM, hypertension or hyperlipidemia, modest weight reduction appeared to improve glycemic control, reduce blood pressure, and reduce cholesterol levels, respectively. Modest weight reduction also appeared to increase longevity in obese individuals. In conclusion, a large proportion of obese individuals with NIDDM, hypertension, and hyperlipidemia experienced positive health benefits with modest weight loss. For patients who are unable to attain and maintain substantial weight reduction, modest weight loss should be recommended; even a small amount of weight loss appears to benefit a substantial subset of obese patients.read more
Citations
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Journal ArticleDOI
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
TL;DR: CB1 blockade with rimonabant 20 mg, combined with a hypocaloric diet over 1 year, promoted significant decrease of bodyweight and waist circumference, and improvement in cardiovascular risk factors.
Journal ArticleDOI
Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes
Rena R. Wing,Wei Lang,Thomas A. Wadden,Monika M. Safford,William C. Knowler,Alain G. Bertoni,James O. Hill,Frederick L. Brancati,Anne L. Peters,Lynne E. Wagenknecht +9 more
TL;DR: Modest weight losses of 5 to <10% were associated with significant improvements in CVD risk factors at 1 year, but larger weight losses had greater benefits.
Bariatric Surgery and Long-term Cardiovascular Events
Lars Sjöström,Markku Peltonen,Peter Jacobson,C. David Sjöström,Kristjan Karason,Hans Wedel,Sofie Ahlin,Åsa Anveden,Calle Bengtsson,Gerd Bergmark,Claude Bouchard,Björn Carlsson,Sven Dahlgren,Jan Karlsson,Anna Karin Lindroos,Hans Lönroth,Kristina Narbro,Ingmar Näslund,Torsten Olbers,Per-Arne Svensson,Lena M. S. Carlsson +20 more
TL;DR: Compared with usual care, bariatric surgery was associated with reduced number of cardiovascular deaths and lower incidence of cardiovascular events in obese adults.
Journal ArticleDOI
Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation
Samuel Klein,Lora E. Burke,George A. Bray,Steven N. Blair,David B. Allison,Xavier Pi-Sunyer,Yuling Hong,Robert H. Eckel +7 more
TL;DR: In this article, the American Heart Association Council on Nutrition, Physical Activity, and Metabolism reviewed the relationship between obesity and the cardiovascular system, evaluated the effect of weight loss on coronary heart disease risk factors, and provided practical weight management treatment guidelines for cardiovascular healthcare professionals.
Journal ArticleDOI
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Robin Christensen,Pernelle Kruse Kristensen,Pernelle Kruse Kristensen,Else Marie Bartels,Henning Bliddal,Arne Astrup +5 more
TL;DR: The findings suggest that 20 mg per day rimonabant increases the risk of psychiatric adverse events--ie, depressed mood disorders and anxiety-despite depressed mood being an exclusion criterion in these trials.
References
More filters
Journal ArticleDOI
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
TL;DR: CB1 blockade with rimonabant 20 mg, combined with a hypocaloric diet over 1 year, promoted significant decrease of bodyweight and waist circumference, and improvement in cardiovascular risk factors.
Journal ArticleDOI
Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes
Rena R. Wing,Wei Lang,Thomas A. Wadden,Monika M. Safford,William C. Knowler,Alain G. Bertoni,James O. Hill,Frederick L. Brancati,Anne L. Peters,Lynne E. Wagenknecht +9 more
TL;DR: Modest weight losses of 5 to <10% were associated with significant improvements in CVD risk factors at 1 year, but larger weight losses had greater benefits.
Bariatric Surgery and Long-term Cardiovascular Events
Lars Sjöström,Markku Peltonen,Peter Jacobson,C. David Sjöström,Kristjan Karason,Hans Wedel,Sofie Ahlin,Åsa Anveden,Calle Bengtsson,Gerd Bergmark,Claude Bouchard,Björn Carlsson,Sven Dahlgren,Jan Karlsson,Anna Karin Lindroos,Hans Lönroth,Kristina Narbro,Ingmar Näslund,Torsten Olbers,Per-Arne Svensson,Lena M. S. Carlsson +20 more
TL;DR: Compared with usual care, bariatric surgery was associated with reduced number of cardiovascular deaths and lower incidence of cardiovascular events in obese adults.
Journal ArticleDOI
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Robin Christensen,Pernelle Kruse Kristensen,Pernelle Kruse Kristensen,Else Marie Bartels,Henning Bliddal,Arne Astrup +5 more
TL;DR: The findings suggest that 20 mg per day rimonabant increases the risk of psychiatric adverse events--ie, depressed mood disorders and anxiety-despite depressed mood being an exclusion criterion in these trials.
Journal ArticleDOI
Using Internet Technology to Deliver a Behavioral Weight Loss Program
TL;DR: In this paper, the authors evaluated whether a structured Internet behavioral weight loss program produces greater initial weight loss and changes in waist circumference than a weight loss education Web site and found that participants who were given a structured behavioral treatment program with weekly contact and individualized feedback had better weight loss compared with those given links to educational Web sites.