Journal ArticleDOI
Binding of dipeptides and tripeptides containing lysine or arginine by p-sulfonatocalixarenes in water: NMR and microcalorimetric studies
Nathalie Douteau-Guével,Florent Perret,Anthony W. Coleman,Jean-Pierre Morel,Nicole Morel-Desrosiers +4 more
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TLDR
The water soluble p-sulfonatocalix[n]arenes (n = 4, 6 and 8) (14, 16 and 18) show glycosylaminoglycan (GAG) mimicry, being both active antithrombotics and modulators of lysyloxidase activity.Abstract:
The water soluble p-sulfonatocalix[n]arenes (n
= 4, 6 and 8) (14, 16 and 18) show glycosylaminoglycan (GAG) mimicry, being both active antithrombotics and modulators of lysyloxidase activity. In order to understand how these synthetic receptors interact with GAG receptor sequences, we have undertaken a study to thermodynamically characterize the binding of dipeptides and tripeptides bearing lysine or arginine residues by 14, 16 and 18 in aqueous buffer at pH 8.0 and 298.15 K. The association constants, enthalpies and entropies of complexation have been determined using titration microcalorimetry. The structure of the complexes
in solution has been studied by 1H NMR spectroscopy. Combining the microcalorimetric data, the binding shifts and the 2D experiments, the nature of the complexation may be clarified.read more
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Noncovalent binding between guanidinium and anionic groups: focus on biological- and synthetic-based arginine/guanidinium interactions with phosph[on]ate and sulf[on]ate residues.
Kevin A. Schug,Wolfgang Lindner +1 more
Journal ArticleDOI
Experimental Binding Energies in Supramolecular Complexes
TL;DR: A critical overview is given on essential noncovalent interactions in synthetic supramolecular complexes, accompanied by analyses with selected proteins, and promises and limitations of these strategies are discussed.
Journal ArticleDOI
Biochemistry of the para -sulfonato-calix[n]arenes
TL;DR: Para-sulfonato-calix[n]arenes have been shown to have potential in the diagnosis of prion-based diseases and their innocuous nature, as far as is known at present, may open up their future use in medications.
Journal ArticleDOI
Recognition of amino acids by functionalized calixarenes
TL;DR: The discussions emphasize the parameters that affect the molecular binding selectivity and efficiency of functionalized calix[n]arenes towards these substrates.
Journal ArticleDOI
Biochemistry of anionic calix[n]arenes
TL;DR: This review treats the biological properties of the various anionic calix[n]arenes, both as soluble forms and in the colloidal state, as well as their interaction with model membranes.
References
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Gabriele S. V. Kuschert,Florence Coulin,Christine A. Power,Amanda E. I. Proudfoot,Rod E. Hubbard,Arlene J. Hoogewerf,Timothy N. C. Wells +6 more
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Journal ArticleDOI
Thermodynamics of molecular recognition by cyclodextrins. 1. Calorimetric titration of inclusion complexation of naphthalenesulfonates with .alpha.-, .beta.-, and .gamma.-cyclodextrins: enthalpy-entropy compensation
TL;DR: In this article, a 1:1 stoichiometry was applied to all of the host-guest combinations employed, except for the inclusion of 2-naphthalenesulfonate 2 with γ-CD.