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Open AccessJournal ArticleDOI

Binding of streptococcal lipoteichoic acid to the fatty acid binding sites on serum albumin.

W A Simpson, +2 more
- 10 Jul 1980 - 
- Vol. 255, Iss: 13, pp 6092-6097
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TLDR
Heterogeneity of the binding sites on the albumin molecule similar to that previously reported for fatty acids was found, and the affinity of binding of lipoteichoic acid to albumin was found to be intermediate between that previous reported for octanoic and palmitic acids, respectively.
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This article is published in Journal of Biological Chemistry.The article was published on 1980-07-10 and is currently open access. It has received 75 citations till now. The article focuses on the topics: Fatty acid binding & Serum albumin.

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Citations
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Journal ArticleDOI

Bacterial Adherence: Adhesin-Receptor Interactions Mediating the Attachment of Bacteria to Mucosal Surfaces

TL;DR: Progress has been made in the development of antiadhesive vaccines directed against the fimbrial adhesins of several human bacterial pathogens, and development of vaccines against bacterial surface components involved in adhesion to mucosal surfaces.
Journal ArticleDOI

The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid.

TL;DR: Using a radiolabeled, secreted form of the type I bovine macrophage scavenger receptor in an in vitro binding assay, it is found that this receptor binds to intact Gram-positive bacteria, including Streptococcus pyogenes, StrePTococcus agalactiae, Staphylococcus aureus, Enterococcus hirae, and Listeria monocytogenes.
Journal ArticleDOI

Multiple adhesins of streptococci.

TL;DR: Human streptococcal isolates are confronted with numerous environmental challenges, one of which is the necessity that they adhere to one or more of the varied mucosal surfaces of the oropharyngeal cavity between their point of entry into the host and the site where physiological conditions favor colonization.
Journal ArticleDOI

Adherence of group A streptococci to fibronectin on oral epithelial cells.

W A Simpson, +1 more
TL;DR: Results suggest that fibronectin on oral epithelial cells serves as a lipoteichoic acid-sensitive receptor for group A streptococci.
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Formation of molecular complexes between a structurally defined M protein and acylated or deacylated lipoteichoic acid of Streptococcus pyogenes.

TL;DR: Results indicate that the LTA molecule is able to bind via its polyanionic backbone to positively charged residues of surface proteins of cells of S. pyogenes.
References
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Journal ArticleDOI

The Attractions of Proteins for Small Molecules and Ions

TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.

TL;DR: It is demonstrated that successful application of affinity chromatography in many cases will critically depend on placing the ligand at a considerable distance from the matrix backbone.
Journal ArticleDOI

Myocardial utilization of carbohydrate and lipids.

TL;DR: Fatty acid uptake was accelerated by increased cardiac work due to an acceleration of carnitine-palmityl CoA transferase and reduced levels of tissue FFA, suggesting that Regulation of fatty acid utilization by the heart is poorly understood.
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