Journal ArticleDOI
Bioaccumulation, oxidative stress, and neurotoxicity in Danio rerio exposed to different isotopic compositions of uranium
TLDR
Oxidative stress induced by uranium exposure led to decreases in superoxide dismutase and catalase activity levels as well as total glutathione content in liver extracts, but significant increase in acetylcholinesterase activity was observed in brain extracts at the same level, whatever the isotopic composition of uranium.Abstract:
Experiments were carried out on adult male zebrafish (Danio rerio) to assess early changes induced by waterborne exposure to different isotopic compositions of uranium (depleted uranium associated or not with 233U). Oxidative stress and neurotoxicity were selected as effect endpoints to characterize uranium chemo- and radiotoxicity. Catalase, glutathione peroxidase, and superoxide dismutase activities and total glutathione content of hepatic extracts, as well as brain acetylcholinesterase activity and uranium bioaccumulation, were measured. Oxidative stress induced by uranium exposure led to decreases in superoxide dismutase and catalase activity levels as well as total glutathione content in liver extracts. These perturbations were significantly more marked in 233U-exposed fish. Furthermore, significant increase in acetylcholinesterase activity was observed in brain extracts at the same level, whatever the isotopic composition of uranium.read more
Citations
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A novel "Integrated Biomarker Response" calculation based on reference deviation concept.
TL;DR: A novel index named “Integrated Biological Responses version 2” based on the reference deviation concept is presented, which allows a clear discrimination of sampling sites as for the IBR, but several differences are observed for contaminated sites according to up- and downregulation of biomarker responses.
Journal ArticleDOI
Health effects of uranium: new research findings.
Doug Brugge,Virginia Buchner +1 more
TL;DR: A review of the health effects of uranium mining, with an emphasis on newer findings (2005–2011) and the update of the toxicologic evidence on uranium adds to the established findings regarding nephrotoxicity, genotoxicity, and developmental defects.
Journal ArticleDOI
Effects of chronic uranium exposure on life history and physiology of Daphnia magna over three successive generations
Sandrine Massarin,Frédéric Alonzo,L. Garcia-Sanchez,Rodolphe Gilbin,Jacqueline Garnier-Laplace,Jean-Christophe Poggiale +5 more
TL;DR: An increasing sensitivity to toxicity was shown across exposed generations with significant effects observed on life history traits and physiology as low as 10 microgL(-1) and a capacity to recover partially in a clean medium after parental exposure to
Journal ArticleDOI
Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure.
TL;DR: Results showed that U is highly bioconcentrated in fish, according to a time- and concentration-dependent model, and hepatic antioxidant defenses, red blood cells DNA integrity and brain acetylcholinesterase activity were found to be significantly altered.
Journal ArticleDOI
Impact of gold nanoparticles on zebrafish exposed to a spiked sediment
TL;DR: Gold accumulation in fish tissues demonstrated the lower bioavailability of AuNP compared to ionic Au, and underlined the higher toxic potential of the nanoparticle form.
References
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Properties, use and health effects of depleted uranium (DU): a general overview.
A. Bleise,P.R. Danesi,W Burkart +2 more
TL;DR: Depleted uranium, a waste product of uranium enrichment, has several civilian and military applications and was used as armor-piercing ammunition in international military conflicts and was claimed to contribute to health problems, known as the Gulf War Syndrome and recently as the Balkan Syndrome.
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