Showing papers in "Journal of Inorganic Biochemistry in 2002"

TL;DR: The toxicity of iron in specific tissues and cell types (liver, macrophages and brain) is illustrated by studies with appropriate cellular and animal models and the prospects for chelation therapy in the treatment and possible prevention of neurodegenerative diseases is reviewed.

TL;DR: The spectroscopic studies together with viscosity experiments and cyclic voltammetry suggest that [CuL(1)](2+) could bind to DNA by partial intercalation via pyridine ring into the base pairs of DNA.

TL;DR: Electrospray mass spectrometry has been used to study metal ion interactions with a set of flavonoids from different classes, establishing for flavones and for the flavanone naringenin that the binding metal sites are preferentially at the 5-hydroxyl and 4-oxo groups.

TL;DR: This review focuses on the recent developments regarding the versatile and striking chemical reactivity of MTs as well as on the existence of conformational/configurational dynamics within their structure.

TL;DR: The bactericidal activity induced by the introduction of silver ions into zeolite was studied and it was demonstrated that all ROS contributed to the activity.

TL;DR: The electronic and vibrational spectra have been calculated with the same method in order to compare them to the experimental spectra and so confirm the involved chelating sites and validate the proposed complex formation mechanism.

TL;DR: The available evidence concerning the mechanism of these enzymes is summarized and a structural comparison between Fe-hydrogenases and related proteins of unknown metal content from yeast, plant, worm, insect and mammals is carried out.

TL;DR: DNA binding affinity increases in the order of [Ru(tpy)(dppt)](2+)<[Ru( tpy)(pta))(ptp)(2+), while the ligand planarity of the complex has a significant effect on DNA binding affinity rises.

TL;DR: Screening of the compounds for their cytotoxicities against T-lymphoblastic leukemia cancer cells has shown that the acetone Schiff base of S-methyldithiocarbazate (Hasme) exhibits a very weak activity, whereas the S-benzyl derivative (Hasbz) is inactive.

TL;DR: Taking inspiration from many chitin-inorganic composites in nature, a number of recent articles throw light on the manufacture of such composites based on calcium carbonate, calcium phosphate and silica, which are important in the field of blood-compatible materials, bone substitutes, and cements for bone repair and reconstruction.

TL;DR: Two thiourea derivatives of methyl anthranilate and their complexes with nickel and platinum show antifungal activity against the major pathogens responsible for important plant diseases (Botrytis cinerea, Colletotrichum fragariae, Fusarium oxysporum and Phoma betae).

TL;DR: Recent developments, from 1995 to the present, in methodology employed in quantification studies of total MT and MT polymorphism are described and general problems associated with determination and evaluation of obtained results are mentioned.

TL;DR: Since bacterial resistance against bacitracin is still rare despite several decades of widespread use, this antibiotic can serve as an ideal lead for the design of potent peptidyl antibiotics lacking bacterial resistance.

TL;DR: In this article, the triclinic space group P-1 with the unit cell parameters a=8.646(2) $\AA, b=12.290(5) \AA, c=14.283(4) ''AA'', α=94.69(2), β=91.60 (3)°, V=1481.7(8)''AA^3'' and Z=2.145(3)

TL;DR: Several metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic and X-ray diffraction methods as mentioned in this paper, and the crystal structure of the four compounds, Na(2)[(Cd(Cx)3)(Cd[Cx]3(H2O))]], 12H 2O, Ni(Cp)2.10H 2 O and Ni[Cp]2.6H 2 2 O, was determined against S. aureus ATCC25923.

TL;DR: The observation of a species whose g axis is almost parallel to the DNA double helical axis has suggested that the phenanthroline moiety intercalates to DNA, and an absence of the intercalated species for the corresponding 2,2'-bipyridine complex has shown that the three-fused aromatic rings in phenan Throline are critical for the interCalative binding of the complexes.

TL;DR: In this article, the authors investigated the push effect of the thiolate ligand in cytochrome P450 using density functional calculations and revealed two energetic factors that contribute to the 'push' effect.

TL;DR: The data not only demonstrate that DU at pH 7 can induced oxidative DNA damage in the absence of significant alpha particle decay, but also suggest that DU can induce carcinogenic lesions, e.g. oxidative DNA lesions, through interaction with a cellular oxygen species.

TL;DR: The wide range of data being obtained on compound I will lead to an understanding of its vital function in peroxidase catalysis and the physiological roles played by these enzymes.

TL;DR: The experiments show that detoxification by GSH is an effective resistance mechanism against dinuclear platinum compounds, however, the dinuclear complexes are less sensitive towards detoxification compared to cisplatin.

TL;DR: Melanin solutions obtained from N-methylated DHI lack the pK(a) 6.3 buffer, consistent with its inability to form the quinone-imine tautomer, and the nature of the metal-binding sites are determined and the binding affinities are quantified.

TL;DR: In this article, the authors report on the interactions of cisplatin and transplatin with two model proteins, ubiquitin (Ub) and horse heart myoglobin (Mb), and attempt to answer the question whether proteins that have methionine-Pt adducts can transfer the platinum to biological nucleophiles and particularly to DNA.

TL;DR: Crystal structures of a thermostable cytochrome P450 (CYP119) and a site-directed mutant, (Phe24Leu), from the acidothermophilic archaea Sulfolobus solfataricus were determined and an analysis of factors contributing to thermostability of CYP119 shows an apparent increase in clustering of aromatic residues and optimum stacking.

TL;DR: The cytotoxicity assay in several human cancer cell lines suggests that the gallium(III) complex might be endowed with promising antitumour properties, and in vitro cytotoxic activity exceeds that of all other tested gallium(-III) complexes.

TL;DR: Both copper complexes with alpha-ketoglutaric acid thiosemicarbazone show proliferation inhibition through an apoptosis mechanism on human leukemia cell lines K562 and U937, while they have no effects on the K562 line.

TL;DR: Biological studies with new thiosemicarbazones derived from natural aldehydes have involved both inhibition of cell proliferation and apoptosis tests in vitro on human leukemia cell line U937 to deepen knowledge on the way these substances interfere with biological processes in leukemic cells.

TL;DR: The CYP121 gene from the pathogenic bacterium Mycobacterium tuberculosis has been cloned and expressed in Escherichia coli, and the protein purified to homogeneity by ion exchange and hydrophobic interaction chromatography suggests that it may represent a novel target for these antibiotics in the M. tuberculosis pathogen.

TL;DR: Recent literature dealing with the chemical composition, structure and mechanism of formation of hemozoin and its synthetic counterpart, beta-hematin, is reviewed.

TL;DR: The results suggest that Cd(2+) binds covalently with DNA (possibly at G, A and T centres) and can form intrastrand bifunctional AT adducts but not the GGAdducts.

TL;DR: It is suggested that MT causes the recruitment of Cu in a Cu-deficient environment by sequestering Cu from degraded Cu-enzymes and delivering it to Cu chaperones.