Open AccessJournal Article
[Biochemistry of Parkinson's disease].
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This article is published in Seikagaku.The article was published on 1988-05-01 and is currently open access. It has received 220 citations till now. The article focuses on the topics: Peptide sequence.read more
Citations
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Journal ArticleDOI
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
Paula Desplats,He Jin Lee,Eun Jin Bae,Christina Patrick,Edward Rockenstein,Leslie Crews,Brian Spencer,Eliezer Masliah,Seung-Jae Lee +8 more
TL;DR: It is shown that α-synuclein is transmitted via endocytosis to neighboring neurons and neuronal precursor cells, forming Lewy-like inclusions, which provide critical insights into the mechanism of pathological progression in PD and other proteinopathies.
Journal ArticleDOI
Ageing and neuronal vulnerability
Mark P. Mattson,Tim Magnus +1 more
TL;DR: Emerging evidence on protein interaction networks that monitor and respond to the normal ageing process suggests that successful neural ageing is possible for most people, but also cautions that cures for neurodegenerative disorders are unlikely in the near future.
Journal ArticleDOI
Expanding insights of mitochondrial dysfunction in Parkinson's disease
TL;DR: How DJ1, PINK1 and OMI/HTRA2 fit into and enhance the understanding of the role of mitochondrial dysfunction in Parkinson's disease are reviewed, and how oxidative stress might be a potential unifying factor in the aetiopathogenesis of the disease is considered.
Book ChapterDOI
Etiology and Pathogenesis of Parkinson’s Disease
Taku Hatano,Nobutaka Hattori +1 more
TL;DR: Genetic factors clearly contribute to the pathogenesis of Parkinson’s disease, and many studies have shed light on their implication in, not only monogenic, but also sporadic forms of PD.
Journal ArticleDOI
Clinical progression in Parkinson disease and the neurobiology of axons.
TL;DR: It is proposed that ongoing degeneration of axons, not cell bodies, is the primary determinant of clinically apparent progression of disease, and that future experimental therapeutics intended to forestall disease progression will benefit from a new focus on the distinct mechanisms of axon degeneration.
References
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Journal ArticleDOI
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
Paula Desplats,He Jin Lee,Eun Jin Bae,Christina Patrick,Edward Rockenstein,Leslie Crews,Brian Spencer,Eliezer Masliah,Seung-Jae Lee +8 more
TL;DR: It is shown that α-synuclein is transmitted via endocytosis to neighboring neurons and neuronal precursor cells, forming Lewy-like inclusions, which provide critical insights into the mechanism of pathological progression in PD and other proteinopathies.
Journal ArticleDOI
Expanding insights of mitochondrial dysfunction in Parkinson's disease
TL;DR: How DJ1, PINK1 and OMI/HTRA2 fit into and enhance the understanding of the role of mitochondrial dysfunction in Parkinson's disease are reviewed, and how oxidative stress might be a potential unifying factor in the aetiopathogenesis of the disease is considered.
Book ChapterDOI
Etiology and Pathogenesis of Parkinson’s Disease
Taku Hatano,Nobutaka Hattori +1 more
TL;DR: Genetic factors clearly contribute to the pathogenesis of Parkinson’s disease, and many studies have shed light on their implication in, not only monogenic, but also sporadic forms of PD.
Journal ArticleDOI
Clinical progression in Parkinson disease and the neurobiology of axons.
TL;DR: It is proposed that ongoing degeneration of axons, not cell bodies, is the primary determinant of clinically apparent progression of disease, and that future experimental therapeutics intended to forestall disease progression will benefit from a new focus on the distinct mechanisms of axon degeneration.
Journal ArticleDOI
Genetic animal models of Parkinson's disease.
TL;DR: The animal models for these genetic causes of PD, including mutations in LRRK2 and alpha-synuclein and mutations in parkin, DJ-1, and PINK1, are discussed, their limitations, and value.