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Open AccessJournal ArticleDOI

Biosynthesis of drosopterins, the red eye pigments of Drosophila melanogaster

Heuijong Kim, +2 more
- 01 Apr 2013 - 
- Vol. 65, Iss: 4, pp 334-340
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TLDR
The characteristics of the Drosophila red eye pigments and of the enzymes and genes involved in its biosynthetic pathway are reviewed.
Abstract
Drosophila melanogaster has red eyes. Scientists have been curious about the biosynthesis of the red eye pigments and have completed a number of investigations on these compounds. Scientific contributions made over the past 50 years have improved our understanding of the red eye pigments. Researchers have elucidated the chemical structures of some pigments and have successfully purified and identified the enzymes that participate in the biosynthesis of the red eye pigments. In this article, we will review the characteristics of the Drosophila red eye pigments and of the enzymes and genes involved in its biosynthetic pathway.

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Citations
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Journal ArticleDOI

Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses.

TL;DR: It is suggested that lethal and sublethal doses of AgNPs, have acute and chronic effects, respectively, on development and longevity by inducing ROS-mediated stress responses.
Journal ArticleDOI

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.

TL;DR: This work reports that Drosophila Prune is a cyclic nucleotide phosphodiesterase that localizes to the mitochondrial matrix and demonstrates the prevalence of mitochondrial cAMP signaling in metazoan and its new role in mitochondrial biogenesis.
Journal ArticleDOI

Biogenesis of zinc storage granules in Drosophila melanogaster.

TL;DR: Drosophila genes required for the biogenesis of lysosome-related organelles (eye pigment granules) also function in the formation of zinc storage granules in the insect's excretory organ, the Malpighian tubules.
Book

Deep Homology?: Uncanny Similarities of Humans and Flies Uncovered by Evo-Devo

Lewis I. Held
TL;DR: Deep homology?
Journal ArticleDOI

A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila.

TL;DR: It is shown that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila and acts as a fat-derived signal that induces satiety by inhibiting the activity of the NPF neurons.
References
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Journal ArticleDOI

Tyrosine hydroxylase. the initial step in norepinephrine biosynthesis.

TL;DR: It has now been possible to demonstrate that brain, adrenal medulla, and sympathetically innervated tissues contain a specific hydroxylase that catalyzes the conversion of L-tyrosine to dopa.
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Tetrahydrobiopterin biosynthesis, regeneration and functions.

TL;DR: Based on gene cloning, recombinant expression, mutagenesis studies, structural analysis of crystals and NMR studies, reaction mechanisms for the biosynthetic and recycling enzymes were proposed, and BH(4) deficiency due to autosomal recessive mutations in all enzymes (except sepiapterin reductase) have been described as a cause of hyperphenylalaninaemia.
Journal ArticleDOI

Identification, characterization, and crystal structure of the Omega class glutathione transferases.

TL;DR: A new class of glutathione transferases has been discovered by analysis of the expressed sequence tag data base and sequence alignment, named Omega, which exhibit an unusual N-terminal extension that abuts the C terminus to form a novel structural unit.
Journal ArticleDOI

Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor

TL;DR: This is the first direct demonstration of tryptophan hydroxylase in this hydroxyindole-rich tissue, and the reaction requires a reduced pteridine and oxygen and is inhibired by Para-Chorophenylalanine.
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