Journal ArticleDOI
Bivalirudin in patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI): 1-year results of a randomised controlled trial
Roxana Mehran,Alexandra J. Lansky,Bernhard Witzenbichler,Giulio Guagliumi,Jan Z. Peruga,Bruce R. Brodie,Dariusz Dudek,Ran Kornowski,Franz Hartmann,Bernard J. Gersh,Stuart J. Pocock,S. Chiu Wong,Eugenia Nikolsky,Louise Gambone,Lynn Vandertie,Helen Parise,George Dangas,Gregg W. Stone +17 more
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TLDR
In patients with STEMI undergoing primary PCI, anticoagulation with bivalirudin reduced the rates of net adverse clinical events and major bleeding at 1 year compared with treatment with heparin plus a GPI.About:
This article is published in The Lancet.The article was published on 2009-10-03. It has received 398 citations till now. The article focuses on the topics: Bivalirudin & Randomized controlled trial.read more
Citations
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Journal ArticleDOI
ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation
Stefan James,Dan Atar,Luigi P. Badano,Carina Blomström Lundqvist,Michael A. Borger,Anthony H. Gershlick,Kurt Huber,Peter Jüni,Mattie J. Lenzen,Kenneth W. Mahaffey,Marco Valgimigli +10 more
TL;DR: The once-in-a-lifetime treatment with Abciximab Intracoronary for acute coronary syndrome and a second dose intravenously for atrial fibrillation is recommended for adults with high blood pressure.
Journal ArticleDOI
Standardized Bleeding Definitions for Cardiovascular Clinical Trials A Consensus Report From the Bleeding Academic Research Consortium
Roxana Mehran,Sunil V. Rao,Deepak L. Bhatt,C. Michael Gibson,Adriano Caixeta,John W. Eikelboom,Sanjay Kaul,Stephen D. Wiviott,Venu Menon,Eugenia Nikolsky,Victor L. Serebruany,Marco Valgimigli,Pascal Vranckx,David P. Taggart,Joseph F. Sabik,Donald E. Cutlip,Mitchell W. Krucoff,E. Magnus Ohman,Philippe Gabriel Steg,Harvey D. White +19 more
TL;DR: Bleeding complications have been associated with an increased risk of subsequent adverse outcomes, including MI, stroke, stent thrombosis, and death, in patients with ACS and in those undergoing percutaneous coronary intervention (PCI) as well as in the long-term antithrombotic setting.
Journal ArticleDOI
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions
Glenn N. Levine,Eric R. Bates,James C. Blankenship,Steven R. Bailey,John A. Bittl,Bojan Cercek,Charles E. Chambers,Stephen G. Ellis,Robert A. Guyton,Steven M. Hollenberg,Umesh N. Khot,Richard A. Lange,Laura Mauri,Roxana Mehran,Issam Moussa,Debabrata Mukherjee,Brahmajee K. Nallamothu,Henry H. Ting,Alice K. Jacobs,Nancy M. Albert,Mark A. Creager,Steven M. Ettinger,Jonathan L. Halperin,Judith S. Hochman,Frederick G. Kushner,E. Magnus Ohman,William G. Stevenson,Clyde W. Yancy +27 more
TL;DR: Alice K. Jacobs, MD, FACC, FAHA, Chair Jeffrey L. Anderson, PhD, CCNS, CCRN, FAH, Chair-Elect - The first female FACC-FAHA board member to be elected in the history of the sport.
Journal ArticleDOI
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention
Glenn N. Levine,Eric R. Bates,James C. Blankenship,Steven R. Bailey,John A. Bittl,Bojan Cercek,Charles E. Chambers,Stephen G. Ellis,Robert A. Guyton,Steven M. Hollenberg,Umesh N. Khot,Richard A. Lange,Laura Mauri,Roxana Mehran,Issam Moussa,Debabrata Mukherjee,Brahmajee K. Nallamothu,Henry H. Ting,Alice K. Jacobs,Jeffrey L. Anderson,Nancy M. Albert,Mark A. Creager,Steven M. Ettinger,Jonathan L. Halperin,Judith S. Hochman,Frederick G. Kushner,E. Magnus Ohman,William G. Stevenson,Clyde W. Yancy +28 more
TL;DR: The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease as mentioned in this paper, and when properly applied, expert analysis of available data on the benefits and risks of these therapies and procedures can
Journal ArticleDOI
Radial Versus Femoral Randomized Investigation in ST-Segment Elevation Acute Coronary Syndrome The RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) Study
Enrico Romagnoli,Giuseppe Biondi-Zoccai,Alessandro Sciahbasi,Luigi Politi,Stefano Rigattieri,Gianluca Pendenza,Francesco Summaria,Roberto Patrizi,Ambra Borghi,Cristian Di Russo,Claudio Moretti,Pierfrancesco Agostoni,Paolo Loschiavo,Ernesto Lioy,Imad Sheiban,Giuseppe Sangiorgi +15 more
TL;DR: Radial access in patients with ST-segment elevation acute coronary syndrome is associated with significant clinical benefits, in terms of both lower morbidity and cardiac mortality, and should become the recommended approach in these patients, provided adequate operator and center expertise is present.
References
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Journal ArticleDOI
Clinical End Points in Coronary Stent Trials A Case for Standardized Definitions
Donald E. Cutlip,Stephan Windecker,Roxana Mehran,Ashley B Boam,David J. Cohen,Gerrit-Anne van Es,P. Gabriel Steg,Marie-Angèle Morel,Laura Mauri,Pascal Vranckx,Eugene P. McFadden,Alexandra J. Lansky,Martial Hamon,Mitchell W. Krucoff,Patrick W. Serruys +14 more
TL;DR: Criteria for assessment of death, myocardial infarction, repeat revascularization, and stent thrombosis were developed and provide consistency across studies that can facilitate the evaluation of safety and effectiveness of these devices.
Journal ArticleDOI
Bivalirudin during Primary PCI in Acute Myocardial Infarction
Gregg W. Stone,Bernhard Witzenbichler,Giulio Guagliumi,Jan Z. Peruga,Bruce R. Brodie,Dariusz Dudek,Ran Kornowski,Franz Hartmann,Bernard J. Gersh,Stuart J. Pocock,George Dangas,S. Chiu Wong,Ajay J. Kirtane,Helen Parise,Roxana Mehran +14 more
TL;DR: In patients with ST-segment elevation myocardial infarction who are undergoing primary PCI, anticoagulation with bivalirudin alone, as compared with heparin plus glycoprotein IIb/IIIa inhibitors, results in significantly reduced 30-day rates of major bleeding and net adverse clinical events.
Journal ArticleDOI
Bivalirudin for Patients with Acute Coronary Syndromes
Gregg W. Stone,Brent T. McLaurin,David A. Cox,Michel E. Bertrand,A. Michael Lincoff,Jeffrey W. Moses,Harvey D. White,Stuart J. Pocock,James H. Ware,Frederick Feit,Antonio Colombo,Philip E. Aylward,Angel Cequier,Harald Darius,Walter Desmet,Ramin Ebrahimi,Martial Hamon,Lars Hvilsted Rasmussen,Hans J. Rupprecht,James W. Hoekstra,Roxana Mehran,E. Magnus Ohman +21 more
TL;DR: In patients with moderate- or high-risk acute coronary syndromes who were undergoing invasive treatment with glycoprotein IIb/IIIa inhibitors, bivalirudin was associated with rates of ischemia and bleeding that were similar to those with heparin.
Journal ArticleDOI
Adverse Impact of Bleeding on Prognosis in Patients With Acute Coronary Syndromes
TL;DR: In ACS patients without persistent ST-segment elevation, there is a strong, consistent, temporal, and dose-related association between bleeding and death, and a similar association was evident between major bleeding and ischemic events, including myocardial infarction and stroke.
Journal ArticleDOI
Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction.
Gregg W. Stone,Cindy L. Grines,David A. Cox,Eulogio García,James E. Tcheng,John J. Griffin,Giulio Guagliumi,Thomas Stuckey,Mark Turco,John D. Carroll,Barry D. Rutherford,Alexandra J. Lansky +11 more
TL;DR: Stent implantation (with or without abciximab therapy) should be considered the routine reperfusion strategy in experienced centers and when used in combination with PTCA, coronary stenting and platelet glycoprotein IIb/IIIa inhibitors may further improve outcomes.
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