Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine.
Renske van Delft,Danielle A.J.E. Lambrechts,Pauline Verschuure,J.A.R.J. Hulsman,Marian Majoie +4 more
Reads0
Chats0
TLDR
BHB correlates better with seizure reduction than do ketones in urine, and it is, therefore, better to use BHB to monitor KD even if BHB is measured less frequently than urinary ketones.Abstract:
Purpose: To investigate whether it is better to use blood beta-hydroxybutyrate (BHB) or urinary ketones to monitor ketogenic diet (KD). Method: In 33 patients on KD we measured ketosis in two different ways. At the 3-monthly visits to the clinic we measured BHB in capillary blood obtained by finger-prick and the level of ketones in the urine using a urine dipstick. If the patient was able to collect urine, the urinary ketones were also measured every day at home. We compared the degree of ketosis with seizure reduction. Results: BHB measured during the 3-monthly visits correlated with seizure reduction at 3 and 6 months (p = 0.037 and 0.019, respectively). Urinary ketones measured at the same time did not correlate at any visit. The averaged values of the daily measured ketones in the urine did not correlate either. Conclusions: BHB correlates better with seizure reduction than do ketones in urine. It is, therefore, better to use BHB to monitor KD even if BHB is measured less frequently than urinary ketones.read more
Citations
More filters
Journal ArticleDOI
Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group
Eric H. Kossoff,Beth Zupec-Kania,Stéphane Auvin,Karen Ballaban-Gil,A. G. Christina Bergqvist,Robyn Blackford,Jeffrey Buchhalter,Roberto Caraballo,J. Helen Cross,Maria Dahlin,Elizabeth J. Donner,Orkide Güzel,Rana S. Jehle,Joerg Klepper,Hoon Chul Kang,Danielle A.J.E. Lambrechts,Y.M. Christiana Liu,Janak K. Nathan,Douglas R. Nordli,Heidi H. Pfeifer,Jong M. Rho,Ingrid E. Scheffer,Suvasini Sharma,Carl E. Stafstrom,Elizabeth A. Thiele,Zahava Turner,María Vaccarezza,Elles J.T.M. van der Louw,Pierangelo Veggiotti,James W. Wheless,Elaine C. Wirrell,Matthew's Friends +31 more
TL;DR: A revised version of this guideline for the management of children on Ketogenic dietary therapies is presented, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation.
Journal ArticleDOI
The ketogenic diet: metabolic influences on brain excitability and epilepsy.
Andrew Lutas,Gary Yellen +1 more
TL;DR: On-going work in these areas that is providing a better understanding of metabolic influences on brain excitability and epilepsy are described.
Journal ArticleDOI
Glucose transporter type I deficiency syndrome: epilepsy phenotypes and outcomes.
Amanda W. Pong,Brianna R. Geary,Kris Engelstad,Ashwini Natarajan,Hong Yang,Darryl C. De Vivo,Darryl C. De Vivo +6 more
TL;DR: The purpose is to describe epilepsy phenotypes in a large Glut 1 DS cohort, to facilitate diagnosis and to describe cases in which non‐KD agents achieved seizure freedom (SF), highlighting potential adjunctive treatments.
Journal ArticleDOI
Mechanisms of Ketogenic Diet Action
Susan A. Masino,Jong M. Rho +1 more
TL;DR: This review highlights the complex interrelationships between reduced seizures and metabolic adaptations that modulate neuronal excitability and may even afford neuroprotection.
Journal ArticleDOI
How Does the Ketogenic Diet Work? Four Potential Mechanisms
TL;DR: Experimental evidence is provided for 4 distinct mechanisms that could contribute to the antiseizure and other beneficial effects of the ketogenic diet.
References
More filters
Journal ArticleDOI
The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial
Elizabeth G Neal,HM Chaffe,Ruby H Schwartz,Margaret S. Lawson,Nicole Edwards,Geogianna Fitzsimmons,Andrea Whitney,J. Helen Cross +7 more
TL;DR: The results from this trial of the ketogenic diet support its use in children with treatment-intractable epilepsy.
Journal ArticleDOI
The efficacy of the ketogenic diet - 1998: A prospective evaluation of intervention in 150 children
John M. Freeman,Eileen P.G. Vining,Diana J. Pillas,Paula L. Pyzik,J. C. Casey,L. a. M. T. Kelly +5 more
TL;DR: The ketogenic diet should be considered as alternative therapy for children with difficult-to-control seizures and is more effective than many of the new anticonvulsant medications and is well tolerated by children and families when it is effective.
Journal ArticleDOI
Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
Eric H. Kossoff,Beth Zupec-Kania,Per Åmark,Karen Ballaban-Gil,A. G. Christina Bergqvist,Robyn Blackford,Jeffrey Buchhalter,Roberto Caraballo,J. Helen Cross,Maria Dahlin,Elizabeth J. Donner,Joerg Klepper,Rana S. Jehle,Heung Dong Kim,Y.M. Christiana Liu,Judy Nation,Douglas R. Nordli,Heidi H. Pfeifer,Jong M. Rho,Carl E. Stafstrom,Elizabeth A. Thiele,Zahava Turner,Elaine C. Wirrell,James W. Wheless,Pierangelo Veggiotti,Eileen P.G. Vining,Anne E. Anderson,Bruce A. Cohen,Mary Currey,Diane Donley,Leon Dure,Bhuwan P. Garg,Michael Goldstein,Brian Grabert,David A. Griesemer,Edward Kovnar,Roger Larson,Agustin Legido,Leslie Anne Morrison,Colette Parker,J. Ben Renfroe,Juergen Schreck,Shlomo Shinnar,Russell Snyder,Carmela Tardo,G. Dean Timmons,Gregory K. Yim +46 more
TL;DR: This paper addresses issues such as patient selection, pre‐KD counseling and evaluation, specific dietary therapy selection, implementation, supplementation, follow‐up management, adverse event monitoring, and eventual KD discontinuation.
Journal ArticleDOI
A multicenter study of the efficacy of the ketogenic diet
Eileen P.G. Vining,John M. Freeman,Karen Ballaban-Gil,Carol Camfield,Peter Camfield,Gregory L. Holmes,Shlomo Shinnar,Robert Shuman,Edwin Trevathan,James W. Wheless +9 more
TL;DR: The ketogenic diet is effective in substantially decreasing difficult-to-control seizures and can successfully be administered in a wide variety of settings.
Journal ArticleDOI
A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy.
Elizabeth G Neal,HM Chaffe,Ruby H Schwartz,Margaret S. Lawson,Nicole Edwards,Georgiana Fitzsimmons,Andrea Whitney,J. Helen Cross +7 more
TL;DR: The first randomized trial on classical and medium‐chain triglyceride (MCT) versions of the ketogenic diet is conducted, examining efficacy and tolerability after 3, 6, and 12 months.
Related Papers (5)
Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
Eric H. Kossoff,Beth Zupec-Kania,Per Åmark,Karen Ballaban-Gil,A. G. Christina Bergqvist,Robyn Blackford,Jeffrey Buchhalter,Roberto Caraballo,J. Helen Cross,Maria Dahlin,Elizabeth J. Donner,Joerg Klepper,Rana S. Jehle,Heung Dong Kim,Y.M. Christiana Liu,Judy Nation,Douglas R. Nordli,Heidi H. Pfeifer,Jong M. Rho,Carl E. Stafstrom,Elizabeth A. Thiele,Zahava Turner,Elaine C. Wirrell,James W. Wheless,Pierangelo Veggiotti,Eileen P.G. Vining,Anne E. Anderson,Bruce A. Cohen,Mary Currey,Diane Donley,Leon Dure,Bhuwan P. Garg,Michael Goldstein,Brian Grabert,David A. Griesemer,Edward Kovnar,Roger Larson,Agustin Legido,Leslie Anne Morrison,Colette Parker,J. Ben Renfroe,Juergen Schreck,Shlomo Shinnar,Russell Snyder,Carmela Tardo,G. Dean Timmons,Gregory K. Yim +46 more