Blood dehydroascorbic acid and diabetes mellitus in human beings.
TLDR
It appears that, in persons having an hereditary predisposition to diabetes, high blood dehydroascorbic acid levels may be used as a marker for early detection of the disease.Abstract:
Ascorbic acid and dehydroascorbic acid were estimated in the blood of normal healthy subjects and diabetic patients. In normal subjects, blood contained only ascorbic acid while dehydroascorbic acid was practically absent. The ascorbic acid level was low in the blood of diabetic patients but the dehydroascorbic acid content was remarkably high, irrespective of age, sex, history of diabetes, or treatment. About 75% of blood dehydroascorbic acid was present in the erythrocytes: the rest was in plasma. High blood dehydroascorbic acid levels were also found in 90% of the non-diabetic offspring with both parents diabetic, in 24% of the non-diabetic offspring with one parent diabetic, and in 75% of the non-diabetic siblings of diabetic patients. It appears that, in persons having an hereditary predisposition to diabetes, high blood dehydroascorbic acid levels may be used as a marker for early detection of the disease.read more
Citations
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When the Pancreas
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Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid
Steven C. Rumsey,Oran Kwon,Guo Wei Xu,Charles F. Burant,Ian A. Simpson,Mark Levine,Mark Levine +6 more
TL;DR: GLUT1 and GLUT3 isoforms are the specific glucose transporter isoforms which mediate DHA transport and subsequent accumulation of AA according to Xenopus laevis oocyte expression system studies.
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Ascorbic acid recycling in human neutrophils.
P Washko,Yaohui Wang,Mark Levine +2 more
TL;DR: Data indicate that vitamin C accumulation is enhanced in activated human neutrophils and that human neutophils utilize and recycle oxidized external vitamin C under physiologic conditions.
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Vitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes Mellitus
Farris K. Timimi,Henry H. Ting,Elizabeth A. Haley,Mary Anne Roddy,Peter Ganz,Mark A. Creager +5 more
TL;DR: Vitamin C selectively restores the impaired endothelium-dependent vasodilation in the forearm resistance vessels of patients with insulin-dependent diabetes mellitus, and indicates that nitric oxide degradation by oxygen-derived free radicals contributes to abnormal vascular reactivity in humans with Diabetes mellitus.
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A highly sensitive high-performance liquid chromatography method for the estimation of ascorbic and dehydroascorbic acid in tissues, biological fluids, and foods.
Willy A. Behrens,René Madère +1 more
TL;DR: The method described here used a specially designed mobile phase, gave greater stability and a noiseless baseline, and increased substantially the sensitivity and precision.
References
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Journal ArticleDOI
When the Pancreas
TL;DR: Dealing with sebaceous carcinoma is important prognostically but sometimes challenging with routine histopathology, androgen receptor (AR) was found to be confirmatory in only 36% of cases and not dependent on the size of the tumor available.
Journal ArticleDOI
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Lest I Forget Thee, Glutathione …
TL;DR: This review of the present situation of glutathione ends with some suggestions for the future.