Blood glucose regulation in type 1 diabetic patients: an adaptive parametric compensation control-based approach
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TLDR
The result indicates that the proposed adaptive control scheme avoids severe hypoglycaemia and gives satisfactory performance under parametric uncertainty highlighting its ability to address the issue of inter‐patient variability.Abstract:
Here, a direct adaptive control strategy with parametric compensation is adopted for an uncertain non-linear model representing blood glucose regulation in type 1 diabetes mellitus patients. The uncertain parameters of the model are updated by appropriate design of adaptation laws using the Lyapunov method. The closed-loop response of the plasma glucose concentration as well as external insulin infusion rate is analysed for a wide range of variation of the model parameters through extensive simulation studies. The result indicates that the proposed adaptive control scheme avoids severe hypoglycaemia and gives satisfactory performance under parametric uncertainty highlighting its ability to address the issue of inter-patient variability.read more
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References
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Journal ArticleDOI
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.
TL;DR: The feasibility of the minimal model technique to determine the etiology of impaired glucose tolerance is demonstrated and it is demonstrated that subjects (regardless of weight) could be segregated into good and lower tolerance by the product of second-phase beta-cell responsivity and insulin sensitivity.
Journal ArticleDOI
Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes
Roman Hovorka,Valentina Canonico,Ludovic J. Chassin,Ulrich Haueter,Massimo Massi-Benedetti,Marco Orsini Federici,Thomas R. Pieber,Helga C. Schaller,Lukas Schaupp,Thomas Vering,Malgorzata E. Wilinska +10 more
TL;DR: Adapt nonlinear model predictive control is promising for the control of glucose concentration during fasting conditions in subjects with type 1 diabetes.
Journal ArticleDOI
Meal Simulation Model of the Glucose-Insulin System
TL;DR: A new simulation model in normal humans that describes the physiological events that occur after a meal, by employing the quantitative knowledge that has become available in recent years, is presented.
Journal ArticleDOI
Artificial Pancreas: Past, Present, Future
TL;DR: The artificial pancreas (AP), known as closed-loop control of blood glucose in diabetes, is a system combining a glucose sensor, a control algorithm, and an insulin infusion device that has proved the feasibility of external glucose control and stimulated further technology development.
Journal ArticleDOI
Diabetes: Models, Signals, and Control
TL;DR: The control of diabetes is an interdisciplinary endeavor, which includes a significant biomedical engineering component, with traditions of success beginning in the early 1960s, and progressed to large-scale in silico experiments, and automated closed-loop control (artificial pancreas).