Botanicals as prospective agents against sars-cov-2 virus
TLDR
Botanicals have a high potential as prospective agents in managing viral diseases and have the potential to result in advances in symptom resolution, decrease disease burden and shorten disease duration.Abstract:
Objective: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus. Methods: This narrative review examined the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus based on the references limited to the English language and published up to February 2022 and retrieved from common academic search engines using multiple keywords and their combinations. The scientific names of plant species were confirmed using World Flora Online (https://wfoplantlist.org/). Results: The role of botanicals in targeting druggable points in the virus replication cycle has been evaluated. This includes the potential role of phytochemicals and medicinal plant concoctions in preventing the virus from entering the cell. Furthermore, the agents have been shown to hinder the attachment of S protein to angiotensin-converting enzyme 2, block RNA-dependent RNA Polymerase, inhibit 3-chymotrypsin like protease, main protease, neuraminidase, and other enzymes involved in virus replication. Special attention was played to the role of botanicals as immunomodulators and adaptogens. Conclusion: Botanicals have a high potential as prospective agents in managing viral diseases. Botanicals' mode of action(s) may be based on their direct interference with the virus's ability to enter human cells, virus replication, or their activation of the immune-modulatory and anti-inflammatory responses. In addition, the adjuvant treatments with botanicals have the potential to result in advances in symptom resolution, decrease disease burden and shorten disease duration. Keywords: COVID-19, botanicals, herbal drugs, Ayurveda, nutraceuticals, phytochemicals, dietary supplements.read more
Citations
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Antiviral effect of the Ferula Kuhistanica Korovin plant, growing in the high-mountain conditions of the Republic of Tajikistan
TL;DR: In this paper , the results of studies on the extract obtained from the root of Ferula kuhistanica Korov, in relation to two strains of the influenza virus: A/Vlad/2/09(H1N1) and A/Almaty/8/98(H3N2), were presented.
References
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Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods.
Canrong Wu,Yang Liu,Yueying Yang,Peng Zhang,Wu Zhong,Yali Wang,Qiqi Wang,Yang Xu,Mingxue Li,Xing-Zhou Li,Mengzhu Zheng,Lixia Chen,Hua Li,Hua Li +13 more
TL;DR: This study systematically analyzed all the proteins encoded by SARS-CoV-2 genes, compared them with proteins from other coronaviruses, predicted their structures, and built 19 structures that could be done by homology modeling and constructed a database of 78 commonly used anti-viral drugs.
Journal ArticleDOI
Mechanisms of SARS-CoV-2 entry into cells.
TL;DR: In this article, structural and cellular foundations for understanding the multistep SARS-CoV-2 entry process, including S protein synthesis, S protein structure, conformational transitions necessary for association of the spike (S) protein with ACE2, engagement of the receptor-binding domain of the S protein with ACS, proteolytic activation of S protein, endocytosis and membrane fusion are provided.
Journal ArticleDOI
Novel antiviral agents: a medicinal plant perspective
Sabah A. A. Jassim,M. A. Naji +1 more
TL;DR: There are innumerable potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridae.
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In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus.
TL;DR: A rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronvirus that causes pneumonia is executed.
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