Brachial-ankle pulse wave velocity as an index of central arterial stiffness.
Shoko Tsuchikura,Tetsuo Shoji,Eiji Kimoto,Kayo Shinohara,Sawako Hatsuda,Hidenori Koyama,Masanori Emoto,Yoshiki Nishizawa +7 more
TLDR
In this paper, an automated device for brachial-ankle pulse wave velocity (baPWV) is used, although information is limited whether it reflects the stiffness of central or peripheral arteries.Abstract:
Aim: Stiffness of the central arteries plays an important role in the pathophysiology of cardiovascular disease, and pulse wave velocity (PWV) of the aorta has been used as the standard measure of central arterial stiffness. An automated device for brachial-ankle (ba) PWV is available, although information is limited whether baPWV reflects the stiffness of central or peripheral arteries. We therefore addressed this question in the present study.Methods: The subjects were 2,806 consecutive participants in our non-invasive vascular laboratory, excluding those with an ankle-brachial index (ABI) lower than 0.95. PWV measurements were simultaneously performed using an automated device for the ba, heart-femoral (hf, aorta), heart-carotid (hc), heart-brachial (hb), and femoral-ankle (fa) segments. Correlational analyses were performed (1) among these PWV values, (2) between PWV and individual risk factors, and (3) between PWV and the Framingham risk score (FRS), a surrogate index for integrated cardiovascular risk.Results: The correlation of baPWV was the highest with hfPWV (r=0.796) and the lowest with hcPWV (r=0.541). Among the known factors preferentially affecting central arterial stiffness, higher age, diabetes mellitus, and chronic kidney disease (CKD) were also closely associated with increased baPWV. Finally, FRS was more closely correlated with hfPWV (r=0.613) and baPWV (r=0.609) than with hbPWV (r=0.523), hcPWV (r=0.509), and faPWV (r=0.393).Conclusion: These results indicate that baPWV is an index of arterial stiffness showing similar characteristics to those of aortic PWV.read more
Citations
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Vascular Dysfunction in Heart Disease
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TL;DR: The topic of prevention is addressed via a review of both modifiable and nonmodifiable risk factors, followed by a survey of recent advances in diagnostic approaches, and the controversial role of endothelial and smooth muscle progenitors in the development of atherosclerosis is presented and discussed.
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Platelet counts are associated with arterial stiffness in Chinese Han population: a longitudinal study.
TL;DR: Elevated PLT counts can increase baPWV in diabetes and are a potential mediator between diabetes and atherosclerosis.
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Arterial stiffness in young women with Turner syndrome using cardio-ankle vascular index
TL;DR: Young women with TS showed increased arterial stiffness measured by CAVI compared to healthy women after adjusting for age, suggesting inherent vasculopathy in TS patients.
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Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment
TL;DR: An increased baPWV was associated with the severity of WMHs, and a lower ABI was associated with cognitive impairment, and management of peripheral vascular disease may help prevent the progression ofWMHs or cognitive decline.
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Relationship between C242T polymorphism and arterial stiffness in an apparently healthy population.
TL;DR: The findings suggest that the C242T gene polymorphism is associated with arterial stiffness, and this relationship could be modified by smoking dose.
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Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
Stéphane Laurent,Pierre Boutouyrie,Roland Asmar,Isabelle Gautier,Brigitte Laloux,Louis Guize,Pierre Ducimetière,Athanase Benetos +7 more
TL;DR: This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.
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Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
Jacques Blacher,Alain P. Guerin,Bruno Pannier,Sylvain J. Marchais,Michel E. Safar,Gérard M. London +5 more
TL;DR: These results provide the first direct evidence that in patients with ESRD, increased aortic stiffness determined by measurement of aorta pulse-wave velocity is a strong independent predictor of all-cause and mainly cardiovascular mortality.
Journal ArticleDOI
Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
TL;DR: Aortic PWV is a powerful independent predictor of mortality in both type 2 diabetes and glucose-tolerance–tested population samples and may represent a useful integrated index of vascular status and hence cardiovascular risk.