Journal ArticleDOI
Brachyury expression predicts poor prognosis at early stages of colorectal cancer
Nerbil Kilic,Susanne Feldhaus,Ergin Kilic,Pierre Tennstedt,Daniel Wicklein,Reinhard von Wasielewski,Christoph Viebahn,Hans Kreipe,Udo Schumacher +8 more
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TLDR
A subset of colorectal cancers exists in which the ability to metastasise is already present at early stages of tumour growth and this high risk group can now be detected by immunohistochemistry.About:
This article is published in European Journal of Cancer.The article was published on 2011-05-01. It has received 77 citations till now. The article focuses on the topics: Cancer & Colorectal cancer.read more
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Regulatory networks defining EMT during cancer initiation and progression
Bram De Craene,Geert Berx +1 more
TL;DR: The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them.
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Epithelial–mesenchymal transition in colorectal cancer metastasis: A system review
TL;DR: This work focuses on the molecular network of the EMT program and its malignant phenotypes associated with metastasis in colorectal cancer (CRC), including cancer stem cells, tumor budding, circulating tumor cells and drug resistance.
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Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread
Elise Pretzsch,Florian Bösch,Jens Neumann,P Ganschow,Alexandr V. Bazhin,Markus Guba,John S. Werner,Martin K. Angele +7 more
TL;DR: In this article, the authors summarize the current status of literature on potential characteristics in tumor biology in the primary tumor, i.e., factors (transcription factors and direct and indirect E-cadherin repressors) and pathways (WNT, TGF-β, and RAS) modulating EMT, regulation of EMT on a posttranscriptional and posttranslational level (miRNAs), and angiogenesis.
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Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury
Christopher R. Heery,B. Harpreet Singh,Myrna Rauckhorst,Jennifer L. Marte,Renee N. Donahue,Italia Grenga,Timothy C. Rodell,William L. Dahut,Philip M. Arlen,Ravi A. Madan,Jeffrey Schlom,James L. Gulley +11 more
TL;DR: This is the first-in-human study to demonstrate the safety and immunogenicity of this therapeutic cancer vaccine and provides the rationale for exploration in phase II studies.
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Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
TL;DR: Functional study found that CTSZ could increase colony formation in soft agar and promote cell motility and the metastatic effect of C TSZ was associated with its role in inducing epithelial-mesenchymal transition (EMT), which played an important role in HCC metastasis.
References
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Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
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Cancer Metastasis: Building a Framework
Gaorav P. Gupta,Joan Massagué +1 more
TL;DR: Understanding of the origins and nature of cancer metastasis and the selection of traits that are advantageous to cancer cells is promoted.
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Epithelial-mesenchymal transitions: twist in development and metastasis.
Yibin Kang,Joan Massagué +1 more
TL;DR: Yang et al. as mentioned in this paper linked EMT to the ability of breast cancer cells to enter the circulation and seed metastases and showed that EMT is vital for morphogenesis during embryonic development and is also implicated in the conversion of early stage tumors into invasive malignancies.
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Parallel progression of primary tumours and metastases
TL;DR: This Perspective draws together data from disease courses, tumour growth rates, autopsy studies, clinical trials and molecular genetic analyses of primary and disseminated tumour cells in support of the parallel progression model.