Journal ArticleDOI
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
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TLDR
The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain.Abstract:
When plasma tryptophan is elevated by the injection of tryptophan or insulin, or by the consumption of carbohydrates, brain tryptophan and serotonin also rise; however, when even larger elevations of plasma tryptophan are produced by the ingestion of protein-containing diets, brain tryptophan and serotonin do not change. The main determinant of brain tryptophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids (that is, tyrosine, phenylalanine, leucine, isoleucine, and valine) that compete with it for uptake into the brain.read more
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References
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Journal ArticleDOI
Brain serotonin content: physiological dependence on plasma tryptophan levels.
TL;DR: Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan and plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrationis that occur nocturnally in untreated aninmals as result of their normal 24-hour rhythms.
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The determination of tryptophan in plasma, liver, and urine.
TL;DR: The specificity of the method is such that, of the compounds tested, only tryptamine produces appreciable fluorescence: one tenth of the molar fluorescence of tryptophan.
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Brain serotonin content - Increase following ingestion of carbohydrate diet.
TL;DR: In the rat, the injection of insulin or the consumption of carbohydrate causes sequential increases in the concentrations of tryptophan in the plasma and the brain and of serotonin in the brain, and serotonin-containing neurons may participate in systems whereby the rat brain integrates information about the metabolic state in its relation to control of homeostatis and behavior.
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The specific binding of L-tryptophan to serum albumin.
Rapier H. McMenamy,J.L. Oncley +1 more
TL;DR: An investigation was undertaken to determine which structural features of tryptophan are responsible for its binding, and to elucidate the nature of the binding site of the protein.
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Substrate specificity of steady-state amino acid transport in mouse brain slices
TL;DR: The substrate specificity of transport was studied in mouse brain slices by measuring the inhibition of uptake of individual amino acids by related compounds, and was found to be similar in many ways to that of other systems.