Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities
Rehák J,Matus Rehak +1 more
TLDR
Grid laser photocoagulation is an established treatment for macular edema in a particular group of patients with BRVO, while promising results for this condition are shown by intravitreal application of steroids or new vascular endothelial growth factor inhibitors.Abstract:
In branch retinal vein occlusion (BRVO), abnormal arteriovenous crossing with vein compression, degenerative changes of the vessel wall and abnormal hematological factors constitute the primary mechanism of vessel occlusion. In general, BRVO has a good prognosis: 50–60% of eyes are reported to have a final visual acuity (VA) of 20/40 or better even without treatment. One important prognostic factor for final VA appears to be the initial VA. Grid laser photocoagulation is an established treatment for macular edema in a particular group of patients with BRVO, while promising results for this condition are shown by intravitreal application of steroids or new vascular endothelial growth factor inhibitors. Vitrectomy with or without arteriovenous sheathotomy combined with removal of the internal limiting membrane may improve vision in eyes with macular edema which are unresponsive to or ineligible for laser treatment.read more
Citations
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Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion.
Julia A. Haller,Francesco Bandello,Rubens Belfort,Mark S. Blumenkranz,Mark C Gillies,Jeffrey S. Heier,Anat Loewenstein,Young-Hee Yoon,Marie-Louise Jacques,Jenny Jiao,Xiao-yan Li,Scott M. Whitcup +11 more
TL;DR: In this paper, the safety and efficacy of dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc., Irvine, CA) compared with sham in eyes with vision loss due to macular edema (ME) associated with BRVO or central retinal vein occlusion (CRVO).
Journal ArticleDOI
Dexamethasone Intravitreal Implant in Patients with Macular Edema Related to Branch or Central Retinal Vein Occlusion: Twelve-Month Study Results
Julia A. Haller,Francesco Bandello,Rubens Belfort,Mark S. Blumenkranz,Mark C Gillies,Jeffrey S. Heier,Anat Loewenstein,Young Hee Yoon,Jenny Jiao,Xiao-yan Li,Scott M. Whitcup +10 more
TL;DR: Among patients with macular edema owing to BRVO or CRVO, single and repeated treatment with DEX implant had a favorable safety profile over 12 months.
Journal ArticleDOI
Natural History of Central Retinal Vein Occlusion: An Evidence-Based Systematic Review
Rachel McIntosh,Sophie Rogers,Lyndell L Lim,Ning Cheung,Jie Jin Wang,Jie Jin Wang,Paul Mitchell,Jonathan W. Kowalski,Hiep Nguyen,Tien Yin Wong,Tien Yin Wong +10 more
TL;DR: Visual acuity generally improved in eyes with BRVO without intervention, although clinically significant improvement beyond 20/40 was uncommon, and the best available evidence from the literature indicated this was uncommon.
Journal ArticleDOI
Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases.
Takeru Yoshimura,Koh Hei Sonoda,Mika Sugahara,Yasutaka Mochizuki,Hiroshi Enaida,Yuji Oshima,Akifumi Ueno,Yasuaki Hata,Hiroki Yoshida,Tatsuro Ishibashi +9 more
TL;DR: Major three factors: IL-6, IL-8, and MCP-1 were strongly correlated with each other indicating a common pathway involved in inflammation process in vitreoretinal diseases.
Journal ArticleDOI
Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature.
TL;DR: An update of the literature about the classification, epidemiology, pathogenesis, risk factors, clinical features, and complications of branch retinal vein occlusion (BRVO), the second most common retinal vascular disorder after diabetic retinopathy, is made.
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