Journal ArticleDOI
Brown adipose tissue mapping in rats with combined intermolecular double-quantum coherence and Dixon water-fat MRI.
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TLDR
A new MRI method is proposed, combining intermolecular double‐quantum coherence and the chemical shift‐encoded Dixon method that provides a novel contrast mechanism and can map BAT distribution exclusively, and was shown to be undetectable by other noninvasive methods.Abstract:
National Natural Science Foundation (NNSF) of China [11174239, 11074209, 81171331]; Fundamental Research Fund for the Central Universities [2010121008, 2010121101]read more
Citations
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Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice
Andrea Armani,Francesca Cinti,Vincenzo Marzolla,James Morgan,Greg A. Cranston,Antonella Antelmi,Giulia Carpinelli,Rossella Canese,Uberto Pagotto,Carmelo Quarta,Walter Malorni,Paola Matarrese,Matteo Marconi,Andrea Fabbri,Giuseppe M.C. Rosano,Saverio Cinti,Morag J. Young,Massimiliano Caprio +17 more
TL;DR: It is shown that adipocyte MR regulates brown remodeling of WAT through a modulation of autophagy, which provides a rationale for the use of MR antagonists to prevent the adverse metabolic consequences of adipocyte dysfunction in high‐fat‐diet‐fed mice.
Journal ArticleDOI
Quantitative proton MR techniques for measuring fat.
Houchun H. Hu,Hermien E. Kan +1 more
TL;DR: The article succinctly describes the principles that differentiate water and fat proton signals, summarizes the advantages and limitations of various techniques and offers a few illustrative examples, and concludes by briefly discussing some future research directions.
Journal ArticleDOI
Non-invasive methods for the assessment of brown adipose tissue in humans.
TL;DR: A review of the currently available methods that non-invasively probe various aspects of BAT biology in order to assess BAT volume and/or metabolism is presented in this paper, where several alternative methods have been developed including different PET approaches, single-photon emission imaging, CT, magnetic resonance based approaches, contrastenhanced ultrasound, near infrared spectroscopy, and temperature assessment of fat depots containing brown adipocytes.
Journal ArticleDOI
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
TL;DR: A comprehensive overview of MR imaging and spectroscopy techniques used to detect BAT in rodents and in humans is provided to provide an outlook on possible future directions of using MRI and MRS in BAT studies.
Journal ArticleDOI
Differentiating brown and white adipose tissues by high-resolution diffusion NMR spectroscopy
Sanjay Kumar Verma,Kaz Nagashima,Jadegoud Yaligar,Navin Michael,Swee Shean Lee,Tian Xianfeng,Venkatesh Gopalan,Suresh Anand Sadananthan,Rengaraj Anantharaj,S. Sendhil Velan,S. Sendhil Velan +10 more
TL;DR: High-resolution pulsed field gradient diffusion NMR spectroscopy is used to study the apparent diffusion coefficient (ADC) of fat molecules in rat BAT and WAT samples to indicate that in vivo diffusion might be a potential way for better delineation of BAT andWAT in both lean and obese states.
References
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Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
Brown adipose tissue activity controls triglyceride clearance
Alexander Bartelt,Oliver T. Bruns,Rudolph Reimer,Heinz Hohenberg,Harald Ittrich,Kersten Peldschus,Michael G. Kaul,Ulrich I. Tromsdorf,Horst Weller,Christian Waurisch,Alexander Eychmüller,Philip L.S.M. Gordts,F. Rinninger,Karoline Bruegelmann,Barbara Freund,Peter Nielsen,Martin Merkel,Joerg Heeren +17 more
TL;DR: It is shown that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice, and Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans.
Journal ArticleDOI
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
Robert S. Garofalo,Stephen J. Orena,Kristina Rafidi,Anthony J. Torchia,Jeffrey L. Stock,Audrey L. Hildebrandt,Timothy M. Coskran,Shawn C Black,Dominique Brees,Joan R. Wicks,John D. McNeish,Kevin Coleman +11 more
TL;DR: The marked hyperglycemia and loss of pancreatic beta cells and adipose tissue in Akt2/PKBbeta-deficient mice suggest that Akt 2/P KBbeta plays critical roles in glucose metabolism and the development or maintenance of proper adipOSE tissue and islet mass for which other Akt/Pkb isoforms are unable to fully compensate.
Journal ArticleDOI
Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) : application with fast spin-echo imaging
Scott B. Reeder,Angel R. Pineda,Zhifei Wen,Ann Shimakawa,Huanzhou Yu,Jean H. Brittain,Garry E. Gold,Christopher H. Beaulieu,Norbert J. Pelc +8 more
TL;DR: Close agreement between theoretical and experimental results obtained from an oil–water phantom was observed, demonstrating that the iterative least‐squares decomposition method is an efficient estimator.
Journal ArticleDOI
Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla
TL;DR: Proton NMR spectroscopy at 7 Tesla offers a simple, fast, noninvasive, and painless method for obtaining detailed information about lipid composition in humans, and the sensitivity and resolution of the method may facilitate longitudinal monitoring of changes in triglyceride composition in response to diet, exercise, and disease.