Open AccessJournal Article
Brown adipose tissue.
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This article is published in The Lancet.The article was published on 1965-07-24 and is currently open access. It has received 494 citations till now. The article focuses on the topics: White adipose tissue & Adipose tissue.read more
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
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Unexpected evidence for active brown adipose tissue in adult humans
TL;DR: It is concluded that a substantial fraction of adult humans possess active brown adipose tissue that thus has the potential to be of metabolic significance for normal human physiology as well as to become pharmaceutically activated in efforts to combat obesity.
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Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Sven Enerbäck,Anders Jacobsson,Elizabeth M. Simpson,Carmen Guerra,Hitoshi Yamashita,Mary-Ellen Harper,Leslie P. Kozak +6 more
TL;DR: In this article, the role of UCP in the regulation of body mass was determined by targeted inactivation of the gene encoding it, and it was found that UCP-deficient mice consume less oxygen after treatment with a β3-adrenergic-receptor agonist and are sensitive to cold, indicating that their thermo-regulation is defective.
Journal ArticleDOI
PGC-1α: a key regulator of energy metabolism
Huiyun Liang,Walter F. Ward +1 more
TL;DR: It is highly likely that PGC-1alpha is intimately involved in disorders such as obesity, diabetes, and cardiomyopathy, which makes it an inviting target for pharmacological intervention in the treatment of obesity and Type 2 diabetes.
Journal ArticleDOI
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Kristin I. Stanford,Roeland J.W. Middelbeek,Kristy L. Townsend,Ding An,Eva B. Nygaard,Kristen M. Hitchcox,Kathleen R. Markan,Kazuhiro Nakano,Michael F. Hirshman,Yu-Hua Tseng,Laurie J. Goodyear +10 more
TL;DR: A previously under-appreciated role for BAT in glucose metabolism is revealed, demonstrating that BAT-derived IL-6 is required for the profound effects of BAT transplantation on glucose homeostasis and insulin sensitivity.