C-H functionalization in the synthesis of amino acids and peptides.
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This article is published in Chemical Reviews.The article was published on 2014-08-21 and is currently open access. It has received 433 citations till now. The article focuses on the topics: Amino acid.read more
Citations
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Transition-Metal-Catalyzed Direct Addition of Unactivated C–H Bonds to Polar Unsaturated Bonds
Lei Yang,Hanmin Huang +1 more
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Metal–Organic Cooperative Catalysis in C–H and C–C Bond Activation
TL;DR: This review discusses various metal-organic cooperative catalytic systems developed for C-H and C-C bond activation reactions, which proceed with high efficiencies and selectivities.
Journal ArticleDOI
Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C–H Functionalization
TL;DR: P palladium-catalyzed bidentate auxiliary-directed C-H functionalization reactions for αAA substrates enable new retrosynthetic logic for the synthesis of many basic αAAs from a common alanine precursor and may facilitate the efficient total synthesis of complex peptide natural products.
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Residue-Specific Peptide Modification: A Chemist’s Guide
TL;DR: This guide will help triage candidate methods for peptide alteration and will serve as a starting point for those seeking to solve long-standing challenges.
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Recent advances in positional-selective alkenylations: removable guidance for twofold C–H activation
TL;DR: Various easily removable or transformable directing groups utilized in the transition metal-catalyzed oxidative C–H alkenylations are discussed in this review until February 2017.
References
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Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
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Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
TL;DR: A review of palladium-catalyzed coupling of CH bonds with organometallic reagents through a PdII/Pd0 catalytic cycle can be found in this paper.
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Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds
Charles S. Yeung,Vy M. Dong +1 more
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Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.
TL;DR: This review summarizes the development and scope of carboxylates as cocatalysts in transition-metal-catalyzed C-H functionalizations until autumn 2010 and proposes new acronyms, such as CMD (concerted metalationdeprotonation), IES (internal electrophilic substitution), or AMLA (ambiphilic metal ligand activation), which describe related mechanisms.
Related Papers (5)
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
Catalytic Functionalization of C(sp2) ? H and C(sp3) ? H Bonds by Using Bidentate Directing Groups
Guy Rouquet,Naoto Chatani +1 more