Open AccessJournal Article
Can biochemical markers predict the severity of hypoxic- ischemic encephalopathy?
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TLDR
Investigating the predictive values of biochemical parameters, including serum creatine kinase (CK), lactate dehydrogenase (LDH), uric acid (UA), and lactate, in newborns with HIE found them to be promising in determining the stage of hypoxia in the laboratory before clinical manifestations occur so that hypothermia treatment can be initiated earlier.Abstract:
Hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia remains an important cause of neonatal morbidity and mortality. The aim of this study was to investigate the predictive values of biochemical parameters, including serum creatine kinase (CK), lactate dehydrogenase (LDH), uric acid (UA), and lactate, in newborns with HIE. A total of 94 patients who were diagnosed with HIE were prospectively enrolled into the study. According to the Sarnat and Sarnat classification, 29 (30.9%) patients had Stage I, 36 (38.3%) Stage II, and 29 (30.9%) Stage III HIE. When CK, LDH, UA, and lactate were used together in order to determine the stage of HIE, specificity and sensitivity were calculated to be 87% and 94%, respectively. Measurement of serum CK, LDH, lactate, and UA levels together is a promising method in determining the stage of hypoxia in the laboratory before clinical manifestations occur so that hypothermia treatment can be initiated earlier.read more
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Journal ArticleDOI
Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.
Hongyan Lv,Qiuli Wang,Sujing Wu,Lihong Yang,Pengshun Ren,Yihui Yang,Jinsheng Gao,Lianxiang Li +7 more
TL;DR: Biomarkers with the greatest potential to predict long-term neurologic handicap of neonates with HIE are GFAP and UCH-L1 and when combined with other markers or brain imaging can increase the detection rate of HIE.
Journal ArticleDOI
Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia: The Hemodynamic Perspective.
TL;DR: It is plausible that ongoing hemodynamic instability, related either to the primary insult or the effects of TH, and the approach to intervention may decrease the effectiveness of neuroprotective strategies by compromising vital organ perfusion and metabolism.
Journal ArticleDOI
Serum Lactate, Brain Magnetic Resonance Imaging and Outcome of Neonatal Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia.
Ming-Chou Chiang,Ming-Chou Chiang,Reyin Lien,Shih-Ming Chu,Peng-Hong Yang,Jainn-Jim Lin,Jainn-Jim Lin,Jen-Fu Hsu,Ren-Huei Fu,Kuang-Lin Lin +9 more
TL;DR: Higher serum level of lactate following TH and abnormal results of brain MRI are associated with poor ND outcome, which is the first report on ND outcome of neonates with HIE treated with TH in Taiwan.
Journal ArticleDOI
Prediction of outcome methods assessing short- and long-term outcome after therapeutic hypothermia
TL;DR: How the reliability of routinely used outcome predictors has changed is reviewed to determine when to best obtain and analyze different clinical, biochemical, and imaging outcome markers to predict outcome in cooled asphyxiated newborns.
Journal ArticleDOI
Biochemical and clinical predictors of hypoxic-ischemic encephalopathy after perinatal asphyxia.
TL;DR: In this work, the Apgar score, troponin T and ALT were found to be strong and useful predictors of HIE.
References
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