Canadian recommendations for laboratory interpretation of multiple or extensive drug resistance in clinical isolates of Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa.
GJ German,M Gilmour,G Tipples,Heather J. Adam,H Almohri,Jared Bullard,Tanis C. Dingle,Farrell D,G Girouard,David Haldane,L Hoang,Paul N. Levett,Roberto G. Melano,Jessica Minion,Robert Needle,Samir N. Patel,Robert Rennie,RC Reyes,Jean Longtin,Michael R. Mulvey +19 more
- Vol. 44, Iss: 1, pp 29-34
TLDR
This is the final edition of the interim recommendations, which were modified after one year of broad consultative review and represents a consensus of peer-reviewed information.Abstract:
The goal of this document was to provide Canadian laboratories with a framework for consistent reporting and monitoring of multidrug resistant organisms (MDRO) and extensively drug resistant organisms (XDRO) for common gram-negative pathogens. This is the final edition of the interim recommendations, which were modified after one year of broad consultative review. This edition represents a consensus of peer-reviewed information and was co-authored by the Canadian Public Health Laboratory Network and the Canadian Association of Clinical Microbiology and Infectious Diseases. There are two main recommendations. The first recommendation provides standardized definitions for MDRO and XDRO for gram-negative organisms in clinical specimens. These definitions were limited to antibiotics that are commonly tested clinically and, to reduce ambiguity, resistance (rather than non-susceptibility) was used to calculate drug resistance status. The second recommendation identifies the use of standardized laboratory reporting of organisms identified as MDRO or XDRO. Through the broad consultation, which included public health and infection prevention and control colleagues, these definitions are ready to be applied for policy development. Both authoring organizations intend to review these recommendations regularly as antibiotic resistance testing evolves in Canada.read more
Citations
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Microbiology Investigation Criteria for Reporting Objectively (MICRO): a framework for the reporting and interpretation of clinical microbiology data.
Paul Turner,Paul Turner,Andrew Fox-Lewis,Andrew Fox-Lewis,Poojan Shrestha,David A. B. Dance,David A. B. Dance,David A. B. Dance,Tri Wangrangsimakul,Tri Wangrangsimakul,Tomas Paul Cusack,Tomas Paul Cusack,Clare L. Ling,Clare L. Ling,Jill Hopkins,Jill Hopkins,Tamalee Roberts,Direk Limmathurotsakul,Ben S. Cooper,Ben S. Cooper,Susanna Dunachie,Susanna Dunachie,Catrin E. Moore,Christiane Dolecek,H. Rogier van Doorn,Philippe J Guerin,Nicholas P. J. Day,Nicholas P. J. Day,Elizabeth A. Ashley +28 more
TL;DR: Implementation of the MICRO checklist will enhance the quality and scientific reporting of clinical microbiology data, increasing data utility and comparability to improve surveillance, grade data quality, facilitate meta-analyses and inform policy and interventions from local to global levels.
Journal ArticleDOI
In Vitro Activity of Imipenem/Relebactam and Ceftolozane/Tazobactam Against Clinical Isolates of Gram-negative Bacilli With Difficult-to-Treat Resistance and Multidrug-resistant Phenotypes-Study for Monitoring Antimicrobial Resistance Trends, United States 2015-2017
James A. Karlowsky,Sibylle H. Lob,Janet Raddatz,Daryl D. DePestel,Katherine Young,Mary Motyl,Daniel F. Sahm +6 more
TL;DR: MDR phenotypes defined using the criteria of Magiorakos et al. may overcall treatment-limiting resistance in Gram-negative bacilli.
Journal ArticleDOI
Characterization of carbapenem-resistant and XDR Pseudomonas aeruginosa in Canada: results of the CANWARD 2007-16 study.
Melissa McCracken,Heather J. Adam,Joseph M Blondeau,Andrew Walkty,James A. Karlowsky,Daryl J. Hoban,George G. Zhanel,Michael R. Mulvey,Canward +8 more
TL;DR: This study characterized carbapenem-resistant and XDR P. aeruginosa isolated from patients receiving care at Canadian hospitals from 2007 to 2016, finding both phenotypes to be genetically diverse and susceptible to colistin and ceftolozane/tazobactam.
Journal ArticleDOI
Consenso latinoamericano para definir, categorizar y notificar patógenos multirresistentes, con resistencia extendida o panresistentes
María Antonieta Jiménez Pearson,Marcelo Galas,Alejandra Corso,Juan Carlos Hormazabal,Carolina Duarte Valderrama,Nuris Salgado Marcano,Pilar Ramon-Pardo,Roberto G. Melano +7 more
TL;DR: Un consenso latinoamericano permite estandarizar las definiciones de los diferentes niveles de resistencia a los antimicrobianos in bacterias de importancia en salud pública.
Journal ArticleDOI
Results from the Canadian Nosocomial Infection Surveillance Program for detection of carbapenemase-producing Acinetobacter spp. in Canadian hospitals, 2010-16.
David A. Boyd,Laura F. Mataseje,Linda Pelude,Robyn Mitchell,Elizabeth Bryce,Diane Roscoe,Joanne Embree,Kevin Katz,Pamela Kibsey,Christian Lavallée,Andrew E. Simor,Geoffrey Taylor,Nathalie Turgeon,Joanne M. Langley,Kanchana Amaratunga,Michael R. Mulvey +15 more
TL;DR: CRA remains uncommon in Canadian hospitals and the incidence did not increase from 2010 to 2016, and almost half of the cases were from two clusters harbouring OXA-235-group enzymes.
References
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Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more
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EUCAST expert rules in antimicrobial susceptibility testing
Roland Leclercq,Rafael Cantón,Derek J. Brown,Christian G. Giske,P. Heisig,Alasdair P. MacGowan,Johan W. Mouton,Patrice Nordmann,Arne C. Rodloff,Gian Maria Rossolini,Claude-James Soussy,Martin Steinbakk,T.G. Winstanley,Gunnar Kahlmeter +13 more
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Journal ArticleDOI
Population‐Based Epidemiological Study of Infections Caused by Carbapenem‐Resistant Pseudomonas aeruginosa in the Calgary Health Region: Importance of Metallo‐β‐Lactamase (MBL)–Producing Strains
Kevin B. Laupland,Michael D. Parkins,Deirdre L. Church,Daniel B. Gregson,Thomas J. Louie,Thomas J. Louie,John Conly,Sameer Elsayed,Johann D. D. Pitout +8 more
TL;DR: MBL-producing P. aeruginosa strains were associated with a higher case-fatality rate and invasive disease, and the potential importance of molecular laboratory techniques in infection control and patient care is highlighted.
Journal ArticleDOI
Carbapenem-resistant Gram-negative bacilli in Canada 2009–10: results from the Canadian Nosocomial Infection Surveillance Program (CNISP)
Laura F. Mataseje,Elizabeth Bryce,Diane Roscoe,David A. Boyd,Joanne Embree,Denise Gravel,Kevin Katz,Pamela Kibsey,M. Kuhn,Aboubaker Mounchili,Andrew E. Simor,Geoff Taylor,Eva Thomas,Nathalie Turgeon,Michael R. Mulvey +14 more
TL;DR: Investigation of isolates from Canadian cases found that carbapenemases were rare at the time of this study and were due to both dominant clones and common plasmid backbones.
Journal ArticleDOI
Multi-drug resistant Acinetobacter infections in critically injured Canadian forces soldiers.
Homer C. Tien,Anthony Battad,Elizabeth Bryce,Jeff Fuller,Michael R. Mulvey,Kathy Bernard,Ronald Brisebois,Jay Doucet,Sandro Rizoli,Robert A. Fowler,Andrew E. Simor +10 more
TL;DR: It is suggested that infection control efforts and further research should be focused on the military field hospital environment to prevent further multi-drug resistant A. baumannii infections in injured soldiers.
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Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more