C
Clare L. Ling
Researcher at University of Oxford
Publications - 50
Citations - 975
Clare L. Ling is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 42 publications receiving 624 citations. Previous affiliations of Clare L. Ling include University College London & Health Protection Agency.
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Journal ArticleDOI
Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors
Aung Pyae Phyo,Aung Pyae Phyo,Elizabeth A. Ashley,Elizabeth A. Ashley,Tim J. Anderson,Zbynek Bozdech,Verena I. Carrara,Kanlaya Sriprawat,Shalini Nair,Marina Mc Dew White,Jerzy Michal Dziekan,Clare L. Ling,Clare L. Ling,Stephane Proux,Kamonchanok Konghahong,Atthanee Jeeyapant,Charles J. Woodrow,Charles J. Woodrow,Mallika Imwong,Rose McGready,Rose McGready,Khin Maung Lwin,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White,François Nosten,François Nosten +27 more
TL;DR: The pivotal factor leading to the declining efficacy of the artemisinin-based combination on the Thailand–Myanmar border (mefloquine–artesunate) to a clinically unacceptable level is the increasing local prevalence of K13 mutations superimposed onto a long-standing background of Pfmdr1 amplification.
Journal ArticleDOI
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from south and southeast Asia
Kelly L. Wyres,To N. T. Nguyen,Margaret M. C. Lam,Louise M. Judd,Nguyen Van Vinh Chau,David A. B. Dance,David A. B. Dance,David A. B. Dance,Margaret Ip,Abhilasha Karkey,Abhilasha Karkey,Clare L. Ling,Clare L. Ling,Thyl Miliya,Paul N. Newton,Paul N. Newton,Paul N. Newton,Nguyen Phu Huong Lan,Amphone Sengduangphachanh,Paul Turner,Paul Turner,Balaji Veeraraghavan,Phat Voong Vinh,Manivanh Vongsouvath,Nicholas R. Thomson,Nicholas R. Thomson,Stephen Baker,Kathryn E. Holt,Kathryn E. Holt +28 more
TL;DR: The study demonstrates how genomics-based surveillance—reporting full molecular profiles including STs, AMR, virulence and serotype locus information—can help standardise comparisons between sites and identify regional differences in pathogen populations.
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Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme
Jordi Landier,Jordi Landier,Daniel M. Parker,Daniel M. Parker,Aung Myint Thu,Khin Maung Lwin,Gilles Delmas,Gilles Delmas,François Nosten,François Nosten,Chiara Andolina,Ricardo Aguas,Saw Moe Ang,Ei Phyo Aung,Naw Baw Baw,Saw Aye Be,Saw B'Let,Hay Bluh,Craig A. Bonnington,Victor Chaumeau,Miasa Chirakiratinant,Win Cho Cho,Peter R. Christensen,Vincent Corbel,Nicholas P. J. Day,Saw Hsa Dah,Mehul Dhorda,Arjen M. Dondorp,Jean Gaudart,Gornpan Gornsawun,Warat Haohankhunnatham,Saw Kyaw Hla,Saw Nay Hsel,Saw Nay Htoo,Mallika Imwong,Saw John,Ladda Kajeechiwa,Lily Kereecharoen,Praphan Kittiphanakun,Keerati Kittitawee,Kamonchanok Konghahong,Saw Diamond Khin,Saw Win Kyaw,Clare L. Ling,Khine Shwe War Lwin,Naw K' Yin Ma,Alexandra Marie,Cynthia Maung,Ed Marta,Myo Chit Minh,Olivo Miotto,Paw Khu Moo,Ku Ler Moo,Merry Moo,Naw Na Na,Mar Nay,Suphak Nosten,Slight Naw Nyo,Eh Kalu Shwe Oh,Phu Thit Oo,Tun Pyit Oo,Eh Shee Paw,Choochai Phumiya,Aung Pyae Phyo,Kasiha Pilaseng,Stephane Proux,Santisuk Rakthinthong,Wannee Ritwongsakul,Kloloi Salathibuphha,Armon Santirad,Sunisa Sawasdichai,Lorenz von Seidlein,Paw Wah Shee,Paw Bway Shee,Decha Tangseefa,May Myo Thwin,Saw Win Tun,Chode Wanachaloemlep,Lisa J. White,Nicholas J. White,Jacher Wiladphaingern,Saw Nyunt Win,Nan Lin Yee,Daraporn Yuwapan +83 more
TL;DR: Providing early diagnosis and effective treatment substantially decreased village-level incidence of artemisinin-resistant P falciparum malaria in hard-to-reach, politically sensitive regions of eastern Myanmar.
Journal ArticleDOI
Detection and identification of bacteria in clinical samples by 16S rRNA gene sequencing: comparison of two different approaches in clinical practice.
Claire Jenkins,Claire Jenkins,Clare L. Ling,Clare L. Ling,Holly Ciesielczuk,Julianne Lockwood,Susan Hopkins,Timothy D. McHugh,Stephen H. Gillespie,Christopher C. Kibbler +9 more
TL;DR: Amplification of shorter fragments of the bacterial 16S rRNA gene resulted in a more sensitive assay; however, analysis of a large fragment (1343 bp) improved species discrimination, making the 762/598 bp PCR more likely to be a more suitable method for the primary detection of theacterial 16SRRNA gene in the clinical setting.
Journal ArticleDOI
Contribution of Asymptomatic Plasmodium Infections to the Transmission of Malaria in Kayin State, Myanmar
Victor Chaumeau,Ladda Kajeechiwa,Bénédicte Fustec,Jordi Landier,Jordi Landier,Saw Naw Nyo,Saw Nay Hsel,Phabele Phatharakokordbun,Prapan Kittiphanakun,Suphak Nosten,May Myo Thwin,Saw Win Tun,Jacher Wiladphaingern,Gilles Cottrell,Daniel M. Parker,Myo Chit Minh,Nittpha Kwansomboon,Selma Metaane,Céline Montazeau,Kitti Kunjanwong,Sunisa Sawasdichai,Chiara Andolina,Chiara Andolina,Clare L. Ling,Clare L. Ling,Warat Haohankhunnatham,Peter Christiensen,Sunaree Wanyatip,Kamonchanok Konghahong,Dominique Cerqueira,Mallika Imwong,Arjen M. Dondorp,Arjen M. Dondorp,Theeraphap Chareonviriyaphap,Nicholas J. White,Nicholas J. White,François Nosten,François Nosten,Vincent Corbel +38 more
TL;DR: Asymptomatic infections are a major source of malaria transmission in Southeast Asia and the impact of MDA on entomological indices has not been characterized previously.