Journal ArticleDOI
Candesartan plus hydrochlorothiazide fixed combination vs previous monotherapy plus diuretic in poorly controlled essential hypertensive patients.
Giuseppe Mancia,Stefano Omboni +1 more
TLDR
CC plus HCTZ fixed combination is an effective and safe alternative to other antihypertensive drugs, given either as monotherapy or in combination when they do not satisfactorily control patient's blood pressure.Abstract:
Objective: To assess efficacy and tolerability of candesartan cilexetil (CC) plus hydrochlorothiazide (HCTZ) fixed combination vs previous monotherapy (PM) plus HCTZ in hypertension. Design and Methods: After 2-4 weeks of run in, 409 outpatients (diastolic blood pressure, DBP >90 and ≤110 mmHg; systolic blood pressure, SBP ≤180 mmHg), aged 26-79 years, under monotherapy, were randomized in a PROBE multicenter trial to CC 16 mg plus HCTZ 12.5 mg or PM plus HCTZ 12.5 mg for 8 weeks. HCTZ was doubled after the first 4 weeks in non-responders (DBP ≥90 mmHg or SBP >180 mmHg). Results: Automatic oscillometric (Omron 705 CP) DBP and SBP were similarly reduced by CC + HCTZ and PM + HCTZ after 4 (12/15 and 10/13 mmHg) and 8 weeks (13/20 and 12/18 mmHg) in the intention-to-treat (ITT, n = 398) population. HCTZ dose was doubled in 18.1 and 31.2% of patients in the CC + HCTZ and PM + HCTZ group, respectively (p < 0.05). Rate of normalized patients (DBP <90 and/or SBP <140 mmHg) after 8 weeks of treat...read more
Citations
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Journal ArticleDOI
Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents. A Meta-Analysis
TL;DR: Compared with free-drug combinations, FDCs of antihypertensive agents are associated with a significant improvement in compliance and with nonsignificant beneficial trends in BP and adverse effects.
Journal ArticleDOI
Pulse pressure - not mean pressure - determines cardiovascular risk in older hypertensive patients
Jerzy Gasowski,Jacques Blacher,Jan A. Staessen,Xavier Girerd,L. Thijs,L. Liu,Ji G. Wang,Robert Fagard,M. Safar +8 more
TL;DR: In older hypertensive patients, pulse pressure not mean pressure is the major determinant of cardiovascular risk, which should be further investigated in randomized controlled outcome trials.
Journal ArticleDOI
Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis
TL;DR: Although the effect estimate suggests that treatment of asymptomatic candidiasis may reduce the risk of preterm birth, the result needs to be interpreted with caution as the primary driver for the pooled estimate comes from a post-hoc (unplanned) subgroup analysis.
Journal ArticleDOI
Fixed-drug combinations as first-line treatment for hypertension.
TL;DR: The "polypill," a fixed combination of multiple agents that address various components of the metabolic syndrome and coexisting common risk factors in both high-risk patients with conditions requiring polypharmacy, and in healthy asymptomatic individuals is suggested.
Journal ArticleDOI
Effectiveness of fixed-dose combination therapy in hypertension: systematic review and meta-analysis.
TL;DR: The FDC treatment is associated with a significant improvement in the cooperation between a doctor and a patient and with increased patients’ adherence to the treatment schedule and it was demonstrated that higher adherence can lead to a lower risk of cardiovascular events.
References
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