Journal ArticleDOI
Carbene-Catalyzed Activation of Formyl-phenylacetic Esters for Access to Chiral Dihydroisoquinolinones.
Shuquan Wu,Jun Xu,Jun Xu,Rui Deng,Hongling Wang,Yonggui Robin Chi,Yonggui Robin Chi,Pengcheng Zheng +7 more
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TLDR
In this article, a carbene-catalyzed reaction to synthesize chiral dihydroisoquinolinones via an o-quinodimethane (o-QDM) intermediate is disclosed.About:
This article is published in Organic Letters.The article was published on 2021-09-17. It has received 3 citations till now. The article focuses on the topics: Annulation & Acylation.read more
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NHC‐catalyzed 1,4‐elimination in the dearomative activation of 3‐furaldehydes towards (4+2)‐cycloadditions
TL;DR: In this paper , a (4+2)-cycloaddition reaction between 2-substituted 3-furaldehydes derivatives and isatins or α,α,α-trifluoroacetophenones as electrophiles has been established under NHC-catalysis.
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NHC-catalyzed N-H functionalization/cycloaddition reaction of indole aldehyde and ketone: A DFT perspective
Lujun Zhang,Yang Wang +1 more
TL;DR: In this paper , the authors theoretically investigated the mechanism and origin of stereoselectivity in N-heterocyclic carbene (NHC)-catalyzed NH functionalization/cycloaddition reaction of indole aldehyde and ketone.
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NHC‐Activations on α‐, β‐, γ‐, and Beyond
TL;DR: In this article , the authors focus on the development of NHC activation of carbonyl carbon (or imine carbon) in situ, α−, β−, γ−, and beyond, and the cycloaddition reaction of these species.
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Journal ArticleDOI
Asymmetric Synthesis of Isoquinoline Alkaloids: 2004–2015
TL;DR: This review describes the stereochemically modified traditional syntheses (the Pictet-Spengler, the Bischler-Napieralski, and the Pomeranz-Fritsch-Bobbitt) along with strategies based on closing of the nitrogen-containing ring B of the isoquinoline core by the formation of bonds between C1-N2, N2-C3, C1
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Tandem oxidation of allylic and benzylic alcohols to esters catalyzed by N-heterocyclic carbenes.
TL;DR: N-heterocyclic carbenes catalyze the oxidation of allylic, propargylic, and benzylic alcohols to esters with manganese(IV) oxide in excellent yields in good yields.
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N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Remote Enantioselective Functionalizations.
TL;DR: This Minireview highlights all the developments and the new advances in NHC-catalyzed asymmetric cycloaddition reactions involving azolium dienolate intermediates.
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The effect of the N-mesityl group in NHC-catalyzed reactions
TL;DR: The N-mesityl group is to render the initial addition of the NHC to the aldehyde irreversible, thereby accelerating the formation of the Breslow intermediate and rationalize the experimentally observed catalyst preference for all classes of NHC-catalyzed reactions of aldehydes and provide a roadmap for catalyst selection and design.