Journal ArticleDOI
Carbene-Catalyzed Activation of Formyl-phenylacetic Esters for Access to Chiral Dihydroisoquinolinones.
Shuquan Wu,Jun Xu,Jun Xu,Rui Deng,Hongling Wang,Yonggui Robin Chi,Yonggui Robin Chi,Pengcheng Zheng +7 more
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TLDR
In this article, a carbene-catalyzed reaction to synthesize chiral dihydroisoquinolinones via an o-quinodimethane (o-QDM) intermediate is disclosed.About:
This article is published in Organic Letters.The article was published on 2021-09-17. It has received 3 citations till now. The article focuses on the topics: Annulation & Acylation.read more
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NHC‐catalyzed 1,4‐elimination in the dearomative activation of 3‐furaldehydes towards (4+2)‐cycloadditions
TL;DR: In this paper , a (4+2)-cycloaddition reaction between 2-substituted 3-furaldehydes derivatives and isatins or α,α,α-trifluoroacetophenones as electrophiles has been established under NHC-catalysis.
Journal ArticleDOI
NHC-catalyzed N-H functionalization/cycloaddition reaction of indole aldehyde and ketone: A DFT perspective
Lujun Zhang,Yang Wang +1 more
TL;DR: In this paper , the authors theoretically investigated the mechanism and origin of stereoselectivity in N-heterocyclic carbene (NHC)-catalyzed NH functionalization/cycloaddition reaction of indole aldehyde and ketone.
Journal ArticleDOI
NHC‐Activations on α‐, β‐, γ‐, and Beyond
TL;DR: In this article , the authors focus on the development of NHC activation of carbonyl carbon (or imine carbon) in situ, α−, β−, γ−, and beyond, and the cycloaddition reaction of these species.
References
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Journal ArticleDOI
Carbene-Catalyzed Enantioselective Decarboxylative Annulations to Access Dihydrobenzoxazinones and Quinolones.
Ansoo Lee,Joshua L. Zhu,Taisiia Feoktistova,Alexander C. Brueckner,Paul Ha-Yeon Cheong,Karl A. Scheidt +5 more
TL;DR: Complementary dispersion-corrected density functional theory (DFT) studies provided an accurate prediction of the reaction enantioselectivity and lend further insight to the origins of stereocontrol.
Journal ArticleDOI
A new approach to asymmetric synthesis of polycycles on the basis of o-quinodimethane generation
Journal ArticleDOI
Hit-to-lead studies for the antimalarial tetrahydroisoquinolone carboxanilides.
David M. Floyd,Philip D. Stein,Zheng Wang,Jian Liu,Steve Castro,Julie Clark,Michele Connelly,Fangyi Zhu,Gloria Holbrook,Amy Matheny,Martina Sigal,Jaeki Min,Rajkumar Dhinakaran,Senthil Krishnan,Sridevi Bashyum,Spencer Knapp,R. Kiplin Guy +16 more
TL;DR: Phenotypic whole-cell screening in erythrocytic cocultures of Plasmodium falciparum identified a series of dihydroisoquinolones that possessed potent antimalarial activity against multiple resistant strains of P. falcIParum in vitro and show no cytotoxicity to mammalian cells in vivo.
Journal ArticleDOI
Synthesis and reactions of a dimetallacyclohexene. Thermal conversion to an o-xylylene complex and phosphine-induced conversion to free o-xylylene and a new reactive dinuclear cobalt complex
Journal ArticleDOI
Addition of N-Heterocyclic Carbene Catalyst to Aryl Esters Induces Remote C-Si Bond Activation and Benzylic Carbon Functionalization.
Hongling Wang,Xingkuan Chen,Yongjia Li,Jilan Wang,Shuquan Wu,Wei Xue,Song Yang,Yonggui Robin Chi,Yonggui Robin Chi +8 more
TL;DR: Through the incorporation of a silicon atom to an aryl carboxylic ester substrate, the resulting C-Si bond can be activated via the addition of a carbene catalyst on a remote site, which allows for efficient functionalization of the benzylic sp3-carbons of aryL carboxYlic esters.