Journal ArticleDOI
Carbonic anhydrases as targets for medicinal chemistry
TLDR
Several important physiological and physio-pathological functions are played by CAs present in organisms all over the phylogenetic tree, related to respiration and transport of carbon dioxide to bicarbonate between metabolizing tissues and the lungs, pH and CO(2) homeostasis, electrolyte secretion in a variety of tissues/organs, biosynthetic reactions, such as the gluconeogenesis and ureagenesis among others.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2007-07-01. It has received 498 citations till now. The article focuses on the topics: Carbonic anhydrase & Enzyme.read more
Citations
More filters
Journal ArticleDOI
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
Journal ArticleDOI
How many carbonic anhydrase inhibition mechanisms exist
TL;DR: Recent findings in the field of CA inhibition may be useful for a structure-based drug design approach of more selective/potent modulators of the activity of these enzymes.
Journal ArticleDOI
Structure-based drug discovery of carbonic anhydrase inhibitors.
TL;DR: Novel drug design strategies have been reported ultimately based on the tail approach for obtaining sulphonamides/DTCs, which exploit more external binding regions within the enzyme active site (in addition to coordination to the metal ion), leading thus to isoform-selective compounds.
Journal ArticleDOI
Carbonic anhydrases--an overview.
TL;DR: Several important physiological and physio-pathological functions are played by CA isozymes present in organisms all over the phylogenetic tree, related to respiration and transport of CO(2)/bicarbonate between metabolizing tissues and the lungs, pH andCO(2) homeostasis, electrolyte secretion in a variety of tissues/organs, biosynthetic reactions, and more.
Journal ArticleDOI
In situ click chemistry: probing the binding landscapes of biological molecules
Sreeman K. Mamidyala,M. G. Finn +1 more
TL;DR: This tutorial review reviews the use of the 1,3-dipolar cycloaddition reaction of organic azides and alkynes in a kinetically-controlled TGS approach, termed in situ click chemistry.
References
More filters
PatentDOI
Carbonic anhydrase inhibitors
Peter Ebbesen,Claudlu T. Supuran,Andrea Scozzafava,Erik Olai Pettersen,Kaye Williams,L.J. Dubois,Philippe Lambin +6 more
TL;DR: A carbonic anhydrase IX (CA IX) inhibitor is a compound of general formula: R-NH-CX-NH-(CH 2 ) n -Ar-Q-SO 2 -NH 2 or a pharmaceutically acceptable salt, derivative or prodrug thereof.
Journal ArticleDOI
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
Eliska Svastova,Alžbeta Hulı́ková,Monika Rafajová,Miriam Zatovicova,Adriana Gibadulinova,Angela Casini,Alessandro Cecchi,Andrea Scozzafava,Claudiu T. Supuran,Jaromir Pastorek,Silvia Pastorekova +10 more
TL;DR: It is shown that hypoxia regulates both expression and activity of CA IX in order to enhance the extracellular acidification, which may have important implications for tumor progression.
Journal ArticleDOI
Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.
TL;DR: The use of such CA inhibitors (CAIs) as antiglaucoma drugs are discussed in detail, together with the recent developments that led to isozyme-specific and organ-selective inhibitors.
Journal ArticleDOI
Prokaryotic carbonic anhydrases
Kerry S. Smith,James G. Ferry +1 more
TL;DR: Recent work has shown that carbonic anhydrase is widespread in metabolically diverse species from both the Archaea and Bacteria domains indicating that the enzyme has a more extensive and fundamental role in prokaryotic biology than previously recognized.
Journal ArticleDOI
A biological function for cadmium in marine diatoms
TL;DR: In this paper, the authors provide evidence of a biological role for Cd in the marine diatom Thalassiosira weissflogii under conditions of low zinc, typical of the marine environment.