Carrageenin‐induced arthritis
D. J. Carmichael,G. C. Gillard,G. C. Gillard,Dennis A. Lowther,Dennis A. Lowther,Dennis A. Lowther,Christopher J. Handley,Christopher J. Handley,V. B. Santer,V. B. Santer +9 more
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A localized inflammatory response was initiated by both single and repeated injections of carrageenin into femorotibial joints, and an inhibition in the in vitro rate of proteoglycan synthesis was detected 72 hours after the injection.Abstract:
A localized inflammatory response was initiated by both single and repeated injections of carrageenin into femorotibial joints. Histologic changes were observed 24 hours after a single intraarticular injection, and an inhibition in the in vitro rate of proteoglycan synthesis was detected 72 hours after the injection. This inhibition was relieved in vitro by the addition of beta-D-xyloside, an exogenous initiator of glycosaminoglycan biosynthesis. Following repeated carrageenin injections, most cells appeared to be dead on histologic examination and no in vitro proteoglycan synthesis could be detected; nor could any stimulation be achieved by adding exyloside.read more
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Book ChapterDOI
The Chemistry of the Ground Substance of Joint Cartilage
TL;DR: This chapter discusses the general composition of cartilage, glycosaminoglycans, keratan sulfate, hyaluronic acid, and proteoglycane, which accounts for about half the dry weight of human adult articular cartilage.
Journal Article
Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death.
W.B. van den Berg,Marijn W. M. Kruijsen,L. B. A. Van De Putte,H J van Beusekom,M van der Sluis-van der Pol,W A Zwarts +5 more
TL;DR: It would appear that, in addition to enzymatic breakdown of cartilage, other phenomena are important in cartilage destruction: inhibition of proteoglycan synthesis and chondrocyte death, apparently unrelated to pannus formation.
Journal ArticleDOI
The mouse patella assay
TL;DR: In this article, an easy method of quantitating articular cartilage chondrocyte function in mice is described, using a defined and anatomically intact cartilage structure, the patella.
Journal ArticleDOI
Juxtaarticular bone loss in experimental inflammatory arthritis.
TL;DR: The osteopenia associated with experimental inflammatory arthritis was studied by a histomorphometric method that exphasized net changes in bone composition and it was calculated that an even greater increase in total bone resorption was responsible for the negative bone balance.
Journal ArticleDOI
Antigen‐induced arthritis. decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage
TL;DR: Cartilage from inflamed joints generally exhibited a decreased ability to synthesize proteoglycan in vitro, and an arthritis induced in rabbits immunized with human serum albumin by injection of antigen into the hind knee joint was noted.
References
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