Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide
TLDR
Findings suggest that in control and phenobarbital-treated rats infused hematin and heme formed in the liver are converted predominantly to bilirubin and CO, appearing in equimolar amounts, and treatment with the porphyrogenic drug AIA shifts the CO/bilirubsin ratio in favor of the gas, and enhances the formation of nonbilirUBin metabolites.Abstract:
Heme catabolism in untreated rats and in animals treated with phenobarbital or porphyrogenic drug, comparing bilirubin and Co productionread more
Citations
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Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Lingyun Wu,Rui Wang +1 more
TL;DR: Understanding of the cellular and molecular mechanisms that regulate the production and mediate the physiological actions of CO has greatly advanced and many diseases, including neurodegenerations, hypertension, heart failure, and inflammation, have been linked to the abnormality in CO metabolism and function.
Journal ArticleDOI
Reactive oxygen species in the regulation of synaptic plasticity and memory.
Cynthia A. Massaad,Eric Klann +1 more
TL;DR: The review shows that the inability to restrain either age- or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.
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Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.
Makoto Suematsu,Nobuhito Goda,Tsuyoshi Sano,Satoshi Kashiwagi,Tsuyoshi Egawa,Yuichi Shinoda,Yuzuru Ishimura +6 more
TL;DR: It is proposed that CO can function as an endogenous modulator of hepatic sinusoidal perfusion through a relaxing mechanism involving Ito cells.
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Binding of CO to myoglobin from a heme pocket docking site to form nearly linear Fe-C-O
TL;DR: These results help to establish how myoglobin discriminates against CO, a controversial issuedominated by the misconception that Fe-C-O is bent.
Journal ArticleDOI
Lipid peroxidation and the degradation of cytochrome P-450 heme.
TL;DR: It appears that different breakdown products of heme are produced by these two mechanisms, unrelated to the degradation of cytochrome P-450 heme by an active metabolite of certain allyl-containing barbiturates and barbiturate related compounds.
References
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Journal ArticleDOI
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
Journal ArticleDOI
The Induction in Vitro of the Synthesis of δ-Aminolevulinic Acid Synthetase in Chemical Porphyria: A Response to Certain Drugs, Sex Hormones, and Foreign Chemicals
TL;DR: Evidence is presented that the control of ALA synthetase in the liver is by feedback repression in which heme may be the corepressor and no feedback inhibition was found.
Journal ArticleDOI
Exchange of heme among hemoglobins and between hemoglobin and albumin.
H F Bunn,James H. Jandl +1 more
TL;DR: Intact heme groups undergo exchange between molecules of human hemoglobin under physiological conditions, although at equilibrium the affinity of human albumin for ferriheme is only about one-fifteenth that of globin.