Journal ArticleDOI
Catalytic Asymmetric Synthesis of Axially Chiral 3,3'‐Bisindoles by Direct Coupling of Indole Rings
TLDR
In this article , a new enantioselective synthesis strategy for axially chiral 3,3'-bisindoles was devised by the direct coupling of two indole rings.Abstract:
A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was devised by the direct coupling of two indole rings. This strategy makes use of the C3-umpolung reactivity of 2-indolylmethanols, which enables the catalytic asymmetric addition reaction of 2-indolylmethanols with rationally designed 2-substituted indoles, thus constructing axially chiral 3,3'-bisindole scaffolds in overall excellent yields (up to 98%) with high enantioselectivities (up to 96 : 4 er). This approach not only has overcome the challenges in constructing axially chiral five-five-membered heterobiaryls, but also represents a new application of the C3-umpolung reactivity of 2-indolylmethanols in asymmetric catalysis. More importantly, this class of axially chiral 3,3'-bisindoles can undergo a variety of post-functionalizations to give axially chiral 3,3'-bisindole-based organocatalysts, which have found their preliminary applications in asymmetric catalysis. Appendix S1: Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. read more
Citations
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Journal ArticleDOI
Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications.
Hong-Hao Zhang,Feng Shi +1 more
TL;DR: In this article , the authors proposed a method for the atropisomeric indole derivatives with axial chirality to synthesize enantioselective transformations of platform molecules.
Journal ArticleDOI
Design and catalytic atroposelective synthesis of axially chiral isochromenone-indoles
Journal ArticleDOI
Organocatalytic Enantioselective Synthesis of Axially Chiral N,N'-Bisindoles.
TL;DR: In this paper , the first organocatalytic enantioselective synthesis of axially chiral N,N'-bisindoles via chiral phosphoric acid-catalyzed formal (3+2) cycloadditions of indole-based enaminones with 2,3-diketoesters was presented.
Journal ArticleDOI
Design and Application of m ‐Hydroxybenzyl Alcohols in Regioselective (3+3) Cycloadditions of 2‐Indolymethanols
Journal ArticleDOI
Chiral phosphoric acid-catalyzed dual-ring formation for enantioselective construction of N-N axially chiral 3,3'-bisquinazolinones.
TL;DR: In this article , a chiral phosphoric acid-catalyzed dual-ring formation strategy was proposed for axially chiral 3,3'-bisquinazolinones with good chemical yields and enantioselectivities.
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Journal ArticleDOI
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