Journal ArticleDOI
Catalytic Synthesis of gamma-Lactams via direct annulations of enals and N-sulfonylimines.
Ming He,Jeffrey W. Bode +1 more
TLDR
In this article, Cinnamaldehydes and N-sulfonylimines undergo direct annulations to cis-disubstituted γ-lactams via the intermediacy of catalytically generated homoenolates.About:
This article is published in Organic Letters.The article was published on 2005-06-09. It has received 242 citations till now.read more
Citations
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Organocatalysis by N-Heterocyclic Carbenes
TL;DR: The inversion of the classical reactivity (Umpolung) opens up new synthetic pathways in biochemical processes as nucleophilic acylations and in nature, the coenzyme thiamine (vitamin B1), a natural thiazolium salt, utilizes a catalytic variant of this concept in biochemical process as nucleophile acylation.
Journal ArticleDOI
Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes.
Journal ArticleDOI
N‐Heterocyclic Carbenes as Organocatalysts
TL;DR: This work highlights the ever-increasing number of reactions that can be promoted by N-heterocyclic carbenes and investigates the role of benzoin condensation in these reactions.
Journal ArticleDOI
Lewis Base Catalysis in Organic Synthesis
TL;DR: It has become increasingly apparent that the behavior of Lewis bases as agents for promoting chemical reactions is not merely as an electronic complement of the cognate Lewis acids: in fact Lewis bases are capable of enhancing both the electrophilic and nucleophilic character of molecules to which they are bound.
Journal ArticleDOI
N-heterocyclic carbene catalyzed domino reactions.
André Grossmann,Dieter Enders +1 more
TL;DR: A critical consideration of domino, cascade, and tandem catalysis in the case of N-heterocyclic carbenes catalysts is presented and recent publications in this area are highlighted.
References
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Journal ArticleDOI
Organocatalyzed conjugate umpolung of α,β-unsaturated aldehydes for the synthesis of γ-butyrolactones
Christian Burstein,Frank Glorius +1 more
Journal ArticleDOI
N-Heterocyclic Carbene-Catalyzed Generation of Homoenolates: γ-Butyrolactones by Direct Annulations of Enals and Aldehydes
TL;DR: This process demonstrates an unprecedented reaction mode for the generation of nucleophilic carbanions with a multifunctional organocatalyst under exceptionally mild and convenient reaction conditions.
Journal ArticleDOI
Conversion of alpha,beta-unsaturated aldehydes into saturated esters: an Umpolung reaction catalyzed by nucleophilic carbenes.
Audrey Chan,Karl A. Scheidt +1 more
TL;DR: In this paper, N-Heterocyclic carbenes derived from benzimidazolium salts are used as catalysts for generating homoenolate species from alpha, β-unsaturated aldehydes.
Journal ArticleDOI
Piracetam and other structurally related nootropics
TL;DR: The piracetam-like nootropics are capable of achieving reversal of amnesia induced by scopolamine, electroconvulsive shock and hypoxia and much evidence points in the direction of a modulated ion flux by, e.g., potentiated calcium influx through non-L-type voltage-dependent calcium channels, potentiated sodium influx through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor gated channels or
Journal ArticleDOI
Catalytic generation of activated carboxylates: Direct, stereoselective synthesis of β-hydroxyesters from epoxyaldehydes
TL;DR: This chemistry unveils a mechanistically viable solution to the catalytic, waste-free synthesis of esters, and provides a new method for the synthesis of anti-aldol adducts.
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Organocatalyzed conjugate umpolung of α,β-unsaturated aldehydes for the synthesis of γ-butyrolactones
Christian Burstein,Frank Glorius +1 more