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Cationic amphiphilic peptides with cancer-selective toxicity
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TLDR
The ability of CAPs to bypass established resistance mechanisms provides an attractive strategy to develop novel lead structures for cancer treatment and Peptidomimetic approaches combined with novel selective delivery devices show promise in overcoming some of these obstacles.About:
This article is published in European Journal of Pharmacology.The article was published on 2009-12-25. It has received 445 citations till now. The article focuses on the topics: Cell-penetrating peptide & Cancer cell.read more
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Antimicrobial peptides: key components of the innate immune system
TL;DR: An overview of cationic antimicrobial peptides, origin, structure, functions, and mode of action of AMPs, which are highly expressed and found in humans, as well as a brief discussion about widely abundant, well characterized AMPs in mammals.
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From antimicrobial to anticancer peptides. a review
TL;DR: An overview of the literature concerning peptides' structure, modes of action, selectivity, and efficacy is provided and some of the many ACPs studied and/or developed for targeting different solid and hematologic malignancies with special emphasis on the first group are summarized.
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Multifunctional Cationic Host Defence Peptides and Their Clinical Applications
TL;DR: An overview of the antimicrobial and immunomodulatory activities of cationic HDPs is provided, and their potential application as beneficial therapeutics in overcoming infectious diseases is discussed.
Journal Article
The antimicrobial peptides and their potential clinical applications
Jun Lei,Li Chun Sun,Li Chun Sun,Siyu Huang,Chenhong Zhu,Ping Li,Jun He,Vienna Mackey,David H. Coy,Quan Yong He +9 more
TL;DR: To open the clinical applications, it is necessary and important to develop the synthetic and long-lasting AMP analogs that overcome the disadvantages of their natural peptides and the potential problems for the drug candidates.
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Biomedical applications of nisin
Jae M. Shin,J.W. Gwak,Pachiyappan Kamarajan,J.C. Fenno,Alexander H. Rickard,Yvonne L. Kapila +5 more
TL;DR: Nisin has now been shown to have antimicrobial activity against both Gram‐positive and Gram‐negative disease‐associated pathogens and can work synergistically in combination with conventional therapeutic drugs.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
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Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.
TL;DR: This review, which is focused on the different stages of membrane permeation induced by representatives of amphipathic alpha-helical antimicrobial and cell non-selective lytic peptides distinguishes between the 'carpet' mechanism, which holds for antimicrobial peptides versus the 'barrel-stave' mechanisms, which hold for cellnon- selective lytics peptides.
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Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
TL;DR: This work has shown that the outer leaflet of eukaryotic plasma membranes is formed predominantly with the cholinephospholipids (sphingomyelin and phosphatidylcholine [PC], whereas the majority of the
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Cationic peptides: a new source of antibiotics
TL;DR: Antimicrobial cationic peptides are an important component of the innate defenses of all species of life as discussed by the authors, and different peptides may have antibacterial, anti-endotoxic, antibiotic-potentiating or antifungal properties.