Studies on anticancer activities of antimicrobial peptides.
TLDR
Various studies on different cationic antimicrobial peptides that exhibit cytotoxic activity against cancer cells are reviewed and the suitability of cancer cell-targeting AMPs as cancer therapeutics is discussed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2008-02-01 and is currently open access. It has received 1114 citations till now. The article focuses on the topics: Antimicrobial peptides & Cancer cell.read more
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Designing antimicrobial peptides: form follows function
TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
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Zinc Oxide Nanoparticles: Synthesis, Antimicrobial Activity and Food Packaging Applications
Paula J.P. Espitia,Nilda de Fátima Ferreira Soares,Jane Sélia dos Reis Coimbra,Nélio José de Andrade,Renato Souza Cruz,Eber Antonio Alves Medeiros +5 more
TL;DR: The main synthesis methods of ZnO nanoparticles, principal characteristics and mechanisms of antimicrobial action as well as the effect of their incorporation in polymeric matrices are discussed in this paper.
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APD2: the updated antimicrobial peptide database and its application in peptide design
Guangshun Wang,Xia Li,Zhe Wang +2 more
TL;DR: Using frequently occurring residues, database-aided peptide design in different ways is demonstrated, and GLK-19 showed a higher activity against Escherichia coli than human LL-37 and Leu, Ala, Gly and Lys in amphibian peptides.
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Antimicrobial peptides: key components of the innate immune system
TL;DR: An overview of cationic antimicrobial peptides, origin, structure, functions, and mode of action of AMPs, which are highly expressed and found in humans, as well as a brief discussion about widely abundant, well characterized AMPs in mammals.
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From antimicrobial to anticancer peptides. a review
TL;DR: An overview of the literature concerning peptides' structure, modes of action, selectivity, and efficacy is provided and some of the many ACPs studied and/or developed for targeting different solid and hematologic malignancies with special emphasis on the first group are summarized.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Cancer statistics, 2006.
Ahmedin Jemal,Rebecca L. Siegel,Elizabeth Ward,Taylor Murray,Jiaquan Xu,Carol Smigal,Michael J. Thun +6 more
TL;DR: The American Cancer Society estimated the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute and mortality data from National Center for Health Statistics as discussed by the authors.
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Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
TL;DR: A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis and appears to represent a previously unrecognized class of vertebrate antimicrobial activities.
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Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.
TL;DR: This review, which is focused on the different stages of membrane permeation induced by representatives of amphipathic alpha-helical antimicrobial and cell non-selective lytic peptides distinguishes between the 'carpet' mechanism, which holds for antimicrobial peptides versus the 'barrel-stave' mechanisms, which hold for cellnon- selective lytics peptides.