Journal ArticleDOI
CD147 and glioma: a meta-analysis
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TLDR
CD147 expression may be a potential prognostic biomarker for poorer overall and relapse-free survival, and may affect the 5-year survival rate in glioma patients.Abstract:
Gliomas are the most common primary brain tumors This meta-analysis aimed to systematically evaluate the relationship between CD147 expression in tissues and the clinicopathological features of patients with glioma We searched PubMed (1966–2016), EMBASE (1980–2016), Cochrane Library (1996–2016), Web of Science (1945–2016), China National Knowledge Infrastructure (1982–2016), and Wan Fang databases (1988–2016) Quality assessment of the literature was performed using the Newcastle–Ottawa Scale, with Revman 53 and Stata 140 for analysis In total, 1806 glioma patients from 19 studies were included, and patients with CD147 overexpression had poorer overall survival [hazard ratio (HR) = 2211, P < 00001], a higher risk of recurrence (HR = 220, P = 00025), and a lower 5-year survival rate [odds ratio (OR) 012; 95% CI 008–019; P < 000001] We observed significant differences in CD147 expression when comparing glioma tissues versus non-cancerous brain tissues (OR 2042; 95% CI 1394–2991; P < 000001), tumor grades III–IV versus grades I–II (OR 588, 95% CI 415–834; P < 000001), and large versus small tumors (OR 158, 95% CI 104–240; P = 003) We also observed a significant correlation with matrix metalloproteinase (MMP) 2 (OR 3911, 95% CI 1147–13334; P < 000001) and MMP9 (OR 1335, 95% CI 467–3818; P < 000001) CD147 expression did not differ based on patient’s age (young vs old, P = 089) or gender (female vs male, P = 057) CD147 expression may be a potential prognostic biomarker for poorer overall and relapse-free survival, and may affect the 5-year survival rate in glioma patients CD147 expression is also closely correlated with poor clinical characteristics in glioma patientsread more
Citations
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CAR T Cell-Based Immunotherapy for the Treatment of Glioblastoma.
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A Lectin-Based Glycomic Approach Identifies FUT8 as a Driver of Radioresistance in Oesophageal Squamous Cell Carcinoma
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The prognostic and clinicopathologic characteristics of CD147 and esophagus cancer: A meta-analysis
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References
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Journal ArticleDOI
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
David N. Louis,Arie Perry,Guido Reifenberger,Andreas von Deimling,Dominique Figarella-Branger,Webster K. Cavenee,Hiroko Ohgaki,Otmar D. Wiestler,Paul Kleihues,David W. Ellison +9 more
TL;DR: The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor and is hoped that it will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors.
Journal ArticleDOI
Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
TL;DR: The quality assessment of non-randomized studies is an important component of a thorough meta-analysis of non randomized studies and can dramatically influence the interpretation of meta-analyses, and can even reverse conclusions regarding the effectiveness of an intervention.
Journal ArticleDOI
Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.
Sue Duval,Richard L. Tweedie +1 more
TL;DR: In this paper, a rank-based data augmentation technique is proposed for estimating the number of missing studies that might exist in a meta-analysis and the effect that these studies might have had on its outcome.
Journal ArticleDOI
Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.
TL;DR: General themes are emerging that yield new strategies for prognosis and therapy of hu- man metastatic cancer, and an imbalanced regulation of motility and proteoly- sis appears to be required for invasion and metastasis.