Journal ArticleDOI
CD44 and SSEA-4 positive cells in an oral cancer cell line HSC-4 possess cancer stem-like cell characteristics.
Zenko Noto,Toshiko Yoshida,Motonori Okabe,Chika Koike,Moustafa Fathy,Hiroaki Tsuno,Kei Tomihara,Naoya Arai,Makoto Noguchi,Toshio Nikaido +9 more
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TLDR
The findings suggest that CD44+SSEA-4+ cells exhibit the characteristics of CSCs in oral squamous cell carcinoma and provide a target for the development of more effective therapies.About:
This article is published in Oral Oncology.The article was published on 2013-08-01. It has received 68 citations till now. The article focuses on the topics: Cancer stem cell & Cancer cell.read more
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Increased Oxidative Stress as a Selective Anticancer Therapy
Jiahui Liu,Zhichong Wang +1 more
TL;DR: The mechanisms of redox regulation in CSCs and the pivotal role of ROS in anticancer treatment are reviewed.
Journal ArticleDOI
Cancer Stem Cells in Oral Cavity Squamous Cell Carcinoma: A Review.
TL;DR: Current knowledge in CSC markers OCT4, SOX2, NANOG, ALDH1, phosphorylated STAT3, CD44, CD24, CD133, and Musashi-1 is examined, specifically focusing on their use and validity in OCSCC CSC research and how they may be organized into the CSC hierarchy.
Journal ArticleDOI
Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers
Yi-Wei Lou,Pao-Yuan Wang,Shih-Chi Yeh,Po-Kai Chuang,Shiou-Ting Li,Chung-Yi Wu,Kay-Hooi Khoo,Michael Hsiao,Tsui-Ling Hsu,Chi-Huey Wong +9 more
TL;DR: It is shown that the glycolipid stage-specific embryonic antigen-4 (SSEA-4) is highly expressed on the surface of both GBM cells and GBM specimens, and it is demonstrated that the growth of GBM tumor is inhibited when anti–S SEA-4 antibody is administered to experimental mice, suggesting a research proof of concept for the treatment GBM
Journal Article
Chemotherapy targeting cancer stem cells.
Haiguang Liu,Lin Lv,Kai Yang +2 more
TL;DR: In this review, a summary of cancer stem cell enrichment methods, the search for new efficient drugs, and the delivery of drugs targeting cancer stem cells are summarized.
PatentDOI
Cell-permeable probes for identification and imaging of sialidases
TL;DR: In this paper, reversible sialidase inhibitors are presented and conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of Sialidases.
References
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TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
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Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
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Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.