Cellular Metabolism in Genetic Transformation of Pneumococci: Requirement for Protein Synthesis During Induction of Competence
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TLDR
Evidence is presented suggesting that, in addition to the competence factor, another specific protein or class of proteins is essential for the development of cellular "competence" in pneumococci.Abstract:
Metabolic inhibitors have differential effects on various phases of genetic transformation in pneumococci. Evidence is presented suggesting that, in addition to the competence factor, another specific protein or class of proteins is essential for the development of cellular “competence.” The precise role of this protein(s) in genetic transformation is not known, but it seems essential for some function subsequent to the interaction of competence factor and cells.read more
Citations
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Characterization of Cell Wall Polymers Secreted into the Growth Medium of Lysis-Defective Pneumococci During Treatment with Penicillin and Other Inhibitors of Cell Wall Synthesis
TL;DR: Autolysin-defective pneumococci secrete large quantities of choline-containing cell wall polymers into the growth medium during treatment with inhibitors of peptidoglycan synthesis.
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Pneumococcus: the sugar-coated bacteria.
TL;DR: The contributions that led to the explosion of knowledge about pneumococcus are discussed and some of the contributions of the group to the understanding of the molecular basis of three important virulence factors: lytic enzymes, pneumococcal phages, and the genes coding for capsular polysaccharides are reported.
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MM1, a Temperate Bacteriophage of the Type 23F Spanish/USA Multiresistant Epidemic Clone of Streptococcus pneumoniae: Structural Analysis of the Site-Specific Integration System
TL;DR: DNAs highly similar to that of MM1 have been detected in several clinical pneumococcal isolates of different capsular types, suggesting a widespread distribution of these phages in relevant pathogenic strains.
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Restriction cleavage maps of the DNAs of Streptococcus pneumoniae bacteriophages containing protein covalently bound to their 5′ ends
TL;DR: The results obtained by electrophoretic analyses as well as by isotopic labelling of these DNAs indicated that all these new phages have a protein covalently linked to the 5′ ends of their DNAs as in the case of Cp-1.
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Mechanism of phage-induced lysis in pneumococci.
TL;DR: It seems that both the host-related and the PAL activities are involved with Dp-1 induced lysis of pneumococci, and the role of the newly discovered phage-associated lysin (PAL) in bacteriophage release and culture lysis is indicated.
References
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The specific inhibition of the DNA-directed RNA synthesis by rifamycin.
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Regulation of the transformability of pneumococcal cultures by macromolecular cell products
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On the Nature of Competence of Transformable Streptococci
R. Pakula,W. Walczak +1 more
TL;DR: Transformable streptococci produce an exocellular factor provoking competence under certain conditions, and non-competent cultures become competent upon addition of this factor.
Journal ArticleDOI
Cyclical behavior in pneumococcal growth and transformability occasioned by environmental changes.
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