Journal ArticleDOI
A study of the genetic material determining an enzyme activity in Pneumococcus
TLDR
It is concluded that genetic properties of markers, such as size, linkage, and discreteness, are reflections of the actual distribution of determinants within DNA molecules.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1960-04-22. It has received 540 citations till now. The article focuses on the topics: DNA & Mutant.read more
Citations
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Journal ArticleDOI
An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps
Katharina Beiter,Florian Wartha,Barbara Albiger,Staffan Normark,Arturo Zychlinsky,Birgitta Henriques-Normark +5 more
TL;DR: Pneumococci are trapped but, unlike many other pathogens, not killed by NETs, and it is demonstrated that escaping NETs promotes spreading of pneumococci from the upper airways to the lungs and from the lungs into the bloodstream during pneumonia.
Journal ArticleDOI
Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization.
TL;DR: The results suggest that phase variation which is marked by differences in colonial morphology may provide insight into the interaction of the pneumococcus with its host.
Journal ArticleDOI
Illustration of Pneumococcal Polysaccharide Capsule during Adherence and Invasion of Epithelial Cells
TL;DR: This study illustrates for the first time the phenotypic variation of the polysaccharide capsule in the initial phase of pneumococcal infections using a modified fixation method that allowed monitoring of the state of capsule expression of pathogens during the infectious process.
Journal ArticleDOI
Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.
TL;DR: The data suggest that interaction of pneumococci with the PAF receptor results in sorting so as to transcytose bacteria across the cell while non-PAF receptor entry shunts bacteria for exit and reentry on the apical surface in a novel recycling pathway.
References
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Journal ArticleDOI
Paper chromatography of some starch conversion products
J. L. Buchan,R. I. Savage +1 more
Journal ArticleDOI
Genetic transformation. II. The significance of damage to the DNA molecule.
Leonard S. Lerman,L.J. Tolmach +1 more
TL;DR: The results indicate a one-hit process for the loss of genetic activity, and are in accord with the hypothesis that cellular incorporation reflects the number average molecular weight of the DNA.
Journal ArticleDOI
Studies on the chemical nature of the substance inducing transformation of pneumococcal types : iii. an improved method for the isolation of the transforming substance and its application to pneumococcus types ii, iii, and vi.
Maclyn McCarty,Oswald T. Avery +1 more
TL;DR: In this second of two direct follow-ups to the 1944 paper on the Transforming Principle, Avery and McCarty provided further details of experimentation which showed that citrate acted as a powerful inhibitor of enzymatic action on DNA, thus resulting in high yields of transforming DNA during experiments.
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