Journal ArticleDOI
Characteristics of response of renal vascular bed to contrast media. Evidence for vasoconstriction induced by renin-angiotensin system.
TLDR
The vasoconstrictor response to contrast media apparently is related to the hyper tonicity of these agents, activation of the renin-angiotensin system and the local conversion of angiotens in I to ang Elliotensin II within the kidney.Abstract:
Three contrast media (mcglumine diatrizoate, meglumine iothalamate and sodium diatrizoate) produced a characteristic biphasic renal hemodynamic response in dogs. An initial transient vasodilatation, which is the common response to contrast media of all vascular beds, was followed by a more prolonged period of vasoconstriction, which is unique to the kidney. Phenoxybenzamine blocked the renal vasoconstriction produced by norepinephrine and 5–hydroxytryptamine but did not influence the biphasic response to the contrast media. The vasoconstriction caused by a bolus of angiotensin or by the contrast media was completely abolished during angiotensin tachyphylaxis, however. Thus, neither norepinephrine nor 5–hydroxytryptamine was involved in mediating the vasoconstriction, whereas angiotensin was implicated. The vasoconstrictor response to contrast media apparently is related to the hyper tonicity of these agents, activation of the renin-angiotensin system and the local conversion of angiotensin I to angiotensin II within the kidney.read more
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Journal ArticleDOI
Variable effects of iodinated contrast media on different rabbit arteries in vitro
TL;DR: Vasoconstriction caused by iodinated contrast media (CM) has contraction potency in arterial vasculature other than the renal artery and found that other arteries also respond with a contraction to CM.
Journal ArticleDOI
Identical mesenteric, femoral and renal vascular responses to angiotensins II and III in the dog
William J.H. Caldicott,William J.H. Caldicott,Kenneth J. Taub,Kenneth J. Taub,Norman K. Hollenberg,Norman K. Hollenberg +5 more
TL;DR: It is concluded that the difference in pressor activity of these agents is attributable to something other than differences in their peripheral vascular receptor, and perhaps may be due to Differences in their central actions.
Journal ArticleDOI
Contrast media nephrotoxicity: comparison of diatrizoate, ioxaglate, and iohexol after intravenous and renal arterial administration.
Dimitrios Koutsikos,I Konstadinidou,D. Mourikis,Dimitrios Rizos,A. Kapetanaki,Basil Agroyannis,Lambros Vlachos +6 more
TL;DR: The results showed that the nephrotoxicity is minimal and equal for all three contrast media and for both routes of their administration, and it was concluded that in this category of patients the far higher cost of the newer low osmolar ionics and nonionics should be considered seriously in regard to neph rotoxicity.
Journal ArticleDOI
Rationale and use of vasodilated excretory urography in screening for renovascular hypertension
TL;DR: The use of dynamic increases in renal size as determined by the technique of vasodilated excretory urography (VEU) is compared with modified rapid-sequence pyelography in a series of 250 hypertensives and size changes are shown to be more accurate than contrast or length disparities.
Journal ArticleDOI
Ca2+ and cyclic adenosine monophosphate involvement in radiographic contrast medium-induced renal vasoconstriction.
TL;DR: Ca2+ influx through VDCC partially contributes to RCM-induced renal artery vasoconstriction, and intracellular cAMP appears to be an important second messenger pathway for prevention of this response.