Journal ArticleDOI
Cigarette smoke-induced DNA damage in cultured human lung cells: role of hydroxyl radicals and endonuclease activation.
Per Leanderson,Christer Tagesson +1 more
TLDR
The findings suggest that the ability of cigarette smoke to cause DNA single strand breaks in cultured lung cells is due to mechanisms involving hydroxyl radical attack on DNA and endonuclease activation, and that hydroquinone is an important contributor to the DNA damaging effect of cigarette Smoke on human lung cells.About:
This article is published in Chemico-Biological Interactions.The article was published on 1992-01-01. It has received 160 citations till now. The article focuses on the topics: DNA damage & Free radical damage to DNA.read more
Citations
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Journal ArticleDOI
Tobacco Smoke Carcinogens and Lung Cancer
TL;DR: By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned.
Journal ArticleDOI
Reactions of oxyl radicals with DNA.
Anthony P. Breen,John A. Murphy +1 more
TL;DR: This review focuses on the damage caused to DNA by reactive oxygen-centred radicals, which arise either from the radiolysis of water by ionizing radiation, or from a purely chemical source.
Journal ArticleDOI
Cancer risk and oxidative DNA damage in man
Steffen Loft,Henrik E. Poulsen +1 more
TL;DR: Human studies support the experimentally based notion of oxidative DNA damage as an important mutagenic and apparently carcinogenic factor in carcinogenesis, but the proof of a causal relationship in humans is still lacking.
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Oxidative stress in chronic obstructive pulmonary disease
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Genotoxicity of tobacco smoke and tobacco smoke condensate: a review.
TL;DR: The data support a model of tobacco Smoke carcinogenesis in which the components of tobacco smoke induce mutations that accumulate in a field of tissue that, through selection, drive the carcinogenic process.
References
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Journal ArticleDOI
Prooxidant states and tumor promotion.
TL;DR: Prooxidant states can be caused by different classes of agents, including hyperbaric oxygen, radiation, xenobiotic metabolites and Fenton-type reagents, modulators of the cytochrome P-450 electron-transport chain, peroxisome proliferators, inhibitors of the antioxidant defense, and membrane-active agents.
Journal ArticleDOI
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
TL;DR: The compounds described are fluorescent Ca2+ indicators absorbing in the ultraviolet region; the very large spectral shifts observed on binding Ca2+, fit the prediction that complexation should hinder the conjugation of the nitrogen lone-pair electrons with the aromatic rings.
Journal ArticleDOI
A scheme for the colorimetric determination of microgram amounts of thiols
Journal ArticleDOI
The role of 8-hydroxyguanine in carcinogenesis.
TL;DR: Article de synthese presentant le role des radicaux libres de l'oxygene impliques dans la formation d'adduits 8-hydroxyguanine (8-OHG) avec l'ADN ou l'ARN.
Journal ArticleDOI
Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation
TL;DR: It was found that ferrous ion, but not ferric ion, was effective in forming 8-OH-dG, and the hydroxyl free radical scavenging agents, thiourea and ethanol, were very effective in quenching Fe(11) mediated 8- OH- dG formation, but superoxide dismutase had very little effect.
Related Papers (5)
Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite.
William A. Pryor,Koni Stone +1 more